FPRP_HUMAN » Prostaglandin F2 receptor negative regulator

FPRP_HUMAN » Prostaglandin F2 receptor negative regulator
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
FPRP_HUMAN » Prostaglandin F2 receptor negative regulator » CD9 partner 1;CD9P-1; Glu-Trp-Ile EWI motif-containing protein F;EWI-F; Prostaglandin F2-alpha receptor regulatory protein;Prostaglandin F2-alpha receptor-associated protein;
Hydrophobic Thickness 26.4 ± 3.2 Å
Tilt Angle 0 ± 1°
ΔGtransfer -33.4 kcal/mol
ΔGfold -9.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 830-850 (830-855)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 26-141, PDBID: 1PKO, Subunit A, Seq Identity:26%, Immunoglobulin V-set domain

AA: 282-390, PDBID: 2BNQ, Subunit D, Seq Identity:26%, Immunoglobulin V-set domain

UniProt annotation for FPRP_HUMAN » Prostaglandin F2 receptor negative regulator
FUNCTION: Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).

SUBUNIT: Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151.

UniProt features for FPRP_HUMAN » Prostaglandin F2 receptor negative regulator
SIGNAL 1 25 Potential.
CHAIN 26 879 Prostaglandin F2 receptor negative regulator.
DOMAIN 26 129 Ig-like C2-type 1.
DOMAIN 149 268 Ig-like C2-type 2.
DOMAIN 276 394 Ig-like C2-type 3.
DOMAIN 406 536 Ig-like C2-type 4.
DOMAIN 544 662 Ig-like C2-type 5.
DOMAIN 688 813 Ig-like C2-type 6.
MOTIF 424 427 Endoplasmic reticulum retention signal.
MOTIF 703 705 Cell attachment site (Potential).
DISULFID 43 119 By similarity.
DISULFID 169 247 By similarity.
DISULFID 299 373 By similarity.
DISULFID 429 515 By similarity.
DISULFID 571 655 By similarity.
DISULFID 711 793 By similarity.
Amino Acid Sequence for FPRP_HUMAN » Prostaglandin F2 receptor negative regulator
MGRLASRPLL LALLSLALCR GRVVRVPTAT LVRVVGTELV IPCNVSDYDG PSEQNFDWSF SSLGSSFVEL ASTWEVGFPA QLYQERLQRG EILLRRTAND AVELHIKNVQ PSDQGHYKCS TPSTDATVQG NYEDTVQVKV LADSLHVGPS ARPPPSLSLR EGEPFELRCT AASASPLHTH LALLWEVHRG PARRSVLALT HEGRFHPGLG YEQRYHSGDV RLDTVGSDAY RLSVSRALSA DQGSYRCIVS EWIAEQGNWQ EIQEKAVEVA TVVIQPSVLR AAVPKNVSVA EGKELDLTCN ITTDRADDVR PEVTWSFSRM PDSTLPGSRV LARLDRDSLV HSSPHVALSH VDARSYHLLV RDVSKENSGY YYCHVSLWAP GHNRSWHKVA EAVSSPAGVG VTWLEPDYQV YLNASKVPGF ADDPTELACR VVDTKSGEAN VRFTVSWYYR MNRRSDNVVT SELLAVMDGD WTLKYGERSK QRAQDGDFIF SKEHTDTFNF RIQRTTEEDR GNYYCVVSAW TKQRNNSWVK SKDVFSKPVN IFWALEDSVL VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLIMAE KPVGDLSSPN ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA GLYRCMVTAW SPVRGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTPS VIRGDLIKLF CIITVEGAAL DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD RKGIVTTSRR DWKSDLSLER VSVLEFLLQV HGSEDQDFGN YYCSVTPWVK SPTGSWQKEA EIHSKPVFIT VKMDVLNAFK YPLLIGVGLS TVIGLLSCLI GYCSSHWCCK KEVQETRRER RRLMSMEMD