FNDC5_HUMAN » Fibronectin type III domain-containing protein 5

FNDC5_HUMAN » Fibronectin type III domain-containing protein 5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FNDC5_HUMAN » Fibronectin type III domain-containing protein 5 » Fibronectin type III repeat-containing protein 2;
Hydrophobic Thickness 34.0 ± 3.2 Å
Tilt Angle 6 ± 3°
ΔGtransfer -26.6 kcal/mol
ΔGfold -17.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 138-159 (138-164)
Pathways none
PDB 4lsd (A/B...=33-130)
OPM none
Complexes

FNDC5:FNDC5_HUMAN

Interactions

FNDC5, Complex: Homodimer of fibronectin type III domain-containing protein 5, PDBID: 4LSD

Domains

AA: 35-117, PDBID: 4LSD, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 149-209, Domain of unknown function (DUF4808)

UniProt annotation for FNDC5_HUMAN » Fibronectin type III domain-containing protein 5
FUNCTION: Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.

TISSUE SPECIFICITY: Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.

INDUCTION: Has been shown to be up-regulated some twofold by muscular exercise at the mRNA and protein level; this effect has been suggested to be mediated by PPARGC1A (PubMed). However, up-regulation upon exercise could not be reproduced, at least not at the mRNA level (PubMed).

UniProt features for FNDC5_HUMAN » Fibronectin type III domain-containing protein 5
SIGNAL 1 31 Potential.
CHAIN 32 212 Fibronectin type III domain-containing protein 5.
CHAIN 32 143 Irisin.
DOMAIN 34 124 Fibronectin type-III.
MOTIF 210 212 Microbody targeting signal (Potential).
Amino Acid Sequence for FNDC5_HUMAN » Fibronectin type III domain-containing protein 5
MRRWLGCVCF ALVQADSPSA PVNVTVRHLK ANSAVVSWDV LEDEVVIGFA ISQQKKDVRM LRFIQEVNTT TRSCALWDLE EDTEYIVHVQ AISIQGQSPA SEPVLFKTPR EAEKMASKNK DEVTMKEMGR NQQLRTGEVL IIVVVLFMWA GVIALFCRQY DIIKDNEPNN NKEKTKSASE TSTPEHQGGG LLRSKI