FND3A_HUMAN » Fibronectin type-III domain-containing protein 3A

FND3A_HUMAN » Fibronectin type-III domain-containing protein 3A
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
FND3A_HUMAN » Fibronectin type-III domain-containing protein 3A » Human gene expressed in odontoblasts;
Hydrophobic Thickness 34.0 ± 1.0 Å
Tilt Angle 4 ± 2°
ΔGtransfer -54.2 kcal/mol
ΔGfold -26.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1172-1196 (1170-1197)
Pathways none
PDB 1wk0 (256-379), 1x3d (361-465), 1x5x (467-562), 2crm (554-660), 2crz (661-757), 1x4x (759-851)
OPM none
Complexes none
Interactions

A4, Complex: FND3A:A4, PubMed

Domains

AA: 267-359, PDBID: 1WK0, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 372-455, PDBID: 1WK0, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 468-552, PDBID: 1X5X, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 567-650, PDBID: 2CRM, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 667-747, PDBID: 2CRZ, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 760-841, PDBID: 1X4X, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 865-940, PDBID: 1X4X, Subunit A, Seq Identity:40%, Fibronectin type III domain

UniProt annotation for FND3A_HUMAN » Fibronectin type-III domain-containing protein 3A
FUNCTION: Mediates spermatid-Sertoli adhesion during spermatogenesis.

TISSUE SPECIFICITY: Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney.

UniProt features for FND3A_HUMAN » Fibronectin type-III domain-containing protein 3A
CHAIN 1 1198 Fibronectin type-III domain-containing protein 3A.
DOMAIN 265 365 Fibronectin type-III 1.
DOMAIN 371 462 Fibronectin type-III 2.
DOMAIN 467 558 Fibronectin type-III 3.
DOMAIN 564 657 Fibronectin type-III 4.
DOMAIN 661 754 Fibronectin type-III 5.
DOMAIN 758 848 Fibronectin type-III 6.
DOMAIN 849 947 Fibronectin type-III 7.
DOMAIN 951 1042 Fibronectin type-III 8.
DOMAIN 1047 1137 Fibronectin type-III 9.
Amino Acid Sequence for FND3A_HUMAN » Fibronectin type-III domain-containing protein 3A
MAEHPPLLDT TQILSSDISL LSAPIVSADG TQQVILVQVN PGEAFTIRRE DGQFQCITGP AQVPMMSPNG SVPPIYVPPG YAPQVIEDNG VRRVVVVPQA PEFHPGSHTV LHRSPHPPLP GFIPVPTMMP PPPRHMYSPV TGAGDMTTQY MPQYQSSQVY GDVDAHSTHG RSNFRDERSS KTYERLQKKL KDRQGTQKDK MSSPPSSPQK CPSPINEHNG LIKGQIAGGI NTGSAKIKSG KGKGGTQVDT EIEEKDEETK AFEALLSNIV KPVASDIQAR TVVLTWSPPS SLINGETDES SVPELYGYEV LISSTGKDGK YKSVYVGEET NITLNDLKPA MDYHAKVQAE YNSIKGTPSE AEIFTTLSCE PDIPNPPRIA NRTKNSLTLQ WKAPSDNGSK IQNFVLEWDE GKGNGEFCQC YMGSQKQFKI TKLSPAMGCK FRLSARNDYG TSGFSEEVLY YTSGCAPSMP ASPVLTKAGI TWLSLQWSKP SGTPSDEGIS YILEMEEETS GYGFKPKYDG EDLAYTVKNL RRSTKYKFKV IAYNSEGKSN PSEVVEFTTC PDKPGIPVKP SVKGKIHSHS FKITWDPPKD NGGATINKYV VEMAEGSNGN KWEMIYSGAT REHLCDRLNP GCFYRLRVYC ISDGGQSAVS ESLLVQTPAV PPGPCLPPRL QGRPKAKEIQ LRWGPPLVDG GSPISCYSVE MSPIEKDEPR EVYQGSEVEC TVSSLLPGKT YSFRLRAANK MGFGPFSEKC DITTAPGPPD QCKPPQVTCR SATCAQVNWE VPLSNGTDVT EYRLEWGGVE GSMQICYCGP GLSYEIKGLS PATTYYCRVQ ALSVVGAGPF SEVVACVTPP SVPGIVTCLQ EISDDEIENP HYSPSTCLAI SWEKPCDHGS EILAYSIDFG DKQSLTVGKV TSYIINNLQP DTTYRIRIQA LNSLGAGPFS HMIKLKTKPL PPDPPRLECV AFSHQNLKLK WGEGTPKTLS TDSIQYHLQM EDKNGRFVSL YRGPCHTYKV QRLNESTSYK FCIQACNEAG EGPLSQEYIF TTPKSVPAAL KAPKIEKVND HICEITWECL QPMKGDPVIY SLQVMLGKDS EFKQIYKGPD SSFRYSSLQL NCEYRFRVCA IRQCQDSLGH QDLVGPYSTT VLFISQRTEP PASTNRDTVE STRTRRALSD EQCAAVILVL FAFFSILIAF IIQYFVIK