FLT3L_HUMAN » Fms-related tyrosine kinase 3 ligand

FLT3L_HUMAN » Fms-related tyrosine kinase 3 ligand
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FLT3L_HUMAN » Fms-related tyrosine kinase 3 ligand » Flt3 ligand; Flt3L; SL cytokine;
Hydrophobic Thickness 29.2 ± 1.4 Å
Tilt Angle 3 ± 0°
ΔGtransfer -32.5 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 185-209 (185-213)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

Pathways in cancer (KEGG)

PDB 1ete (A/B/C/D=27-160), 3qs7 (A/B/C/D=27-160), 3qs9 (A/B/C/D=27-160)
OPM none
Complexes

FLT3:FLT3L_HUMAN

FLT3L:FLT3L_HUMAN

Interactions

FLT3L, Complex: Homodimer of Fms-related tyrosine kinase 3 ligand, PDBID: 1ETE

FLT3, Complex: FLT3L:FLT3, PDBID: 3qs7, PubMed

SCF, Complex: SCF:FLT3L, PubMed

Domains

AA: 29-159, PDBID: 1ETE, Subunit C, Seq Identity:100%, flt3 ligand

UniProt annotation for FLT3L_HUMAN » Fms-related tyrosine kinase 3 ligand
FUNCTION: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

SUBUNIT: Homodimer (isoform 2).

UniProt features for FLT3L_HUMAN » Fms-related tyrosine kinase 3 ligand
SIGNAL 1 26 Potential.
CHAIN 27 235 Fms-related tyrosine kinase 3 ligand.
DISULFID 30 111
DISULFID 70 153
DISULFID 119 158
Amino Acid Sequence for FLT3L_HUMAN » Fms-related tyrosine kinase 3 ligand
MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD YLLQDYPVTV ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER VNTEIHFVTK CAFQPPPSCL RFVQTNISRL LQETSEQLVA LKPWITRQNF SRCLELQCQP DSSTLPPPWS PRPLEATAPT APQPPLLLLL LLPVGLLLLA AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH