FLRT2_HUMAN » Leucine-rich repeat transmembrane protein FLRT2

FLRT2_HUMAN » Leucine-rich repeat transmembrane protein FLRT2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FLRT2_HUMAN » Leucine-rich repeat transmembrane protein FLRT2 » Fibronectin-like domain-containing leucine-rich transmembrane protein 2;
Hydrophobic Thickness 35.6 ± 4.0 Å
Tilt Angle 6 ± 5°
ΔGtransfer -26.6 kcal/mol
ΔGfold -22.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 541-566 (539-568)
Pathways none
PDB none
OPM none
Complexes none
Interactions

FLRT1, Complex: FLRT2:FLRT1, PubMed

Domains

AA: 109-171, PDBID: 4V2C, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 180-242, PDBID: 4V2C, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 252-311, PDBID: 4V2C, Subunit A, Seq Identity:96%, Leucine rich repeat

AA: 336-361, PDBID: 4V2C, Subunit C, Seq Identity:100%, Leucine rich repeat C-terminal domain

AA: 423-496, PDBID: 1MFN, Subunit A, Seq Identity:27%, Fibronectin type III domain

UniProt annotation for FLRT2_HUMAN » Leucine-rich repeat transmembrane protein FLRT2
FUNCTION: May have a function in cell adhesion and/or receptor signaling.

TISSUE SPECIFICITY: Expressed in pancreas, skeletal muscle, brain, and heart.

UniProt features for FLRT2_HUMAN » Leucine-rich repeat transmembrane protein FLRT2
SIGNAL 1 35
CHAIN 36 660 Leucine-rich repeat transmembrane protein FLRT2.
DOMAIN 36 63 LRRNT.
REPEAT 64 85 LRR 1.
REPEAT 89 109 LRR 2.
REPEAT 110 131 LRR 3.
REPEAT 134 155 LRR 4.
REPEAT 160 181 LRR 5.
REPEAT 182 202 LRR 6.
REPEAT 205 225 LRR 7.
REPEAT 231 252 LRR 8.
REPEAT 253 274 LRR 9.
REPEAT 277 298 LRR 10.
DOMAIN 310 362 LRRCT.
DOMAIN 420 510 Fibronectin type-III.
Amino Acid Sequence for FLRT2_HUMAN » Leucine-rich repeat transmembrane protein FLRT2
MGLQTTKWPS HGAFFLKSWL IISLGLYSQV SKLLACPSVC RCDRNFVYCN ERSLTSVPLG IPEGVTVLYL HNNQINNAGF PAELHNVQSV HTVYLYGNQL DEFPMNLPKN VRVLHLQENN IQTISRAALA QLLKLEELHL DDNSISTVGV EDGAFREAIS LKLLFLSKNH LSSVPVGLPV DLQELRVDEN RIAVISDMAF QNLTSLERLI VDGNLLTNKG IAEGTFSHLT KLKEFSIVRN SLSHPPPDLP GTHLIRLYLQ DNQINHIPLT AFSNLRKLER LDISNNQLRM LTQGVFDNLS NLKQLTARNN PWFCDCSIKW VTEWLKYIPS SLNVRGFMCQ GPEQVRGMAV RELNMNLLSC PTTTPGLPLF TPAPSTASPT TQPPTLSIPN PSRSYTPPTP TTSKLPTIPD WDGRERVTPP ISERIQLSIH FVNDTSIQVS WLSLFTVMAY KLTWVKMGHS LVGGIVQERI VSGEKQHLSL VNLEPRSTYR ICLVPLDAFN YRAVEDTICS EATTHASYLN NGSNTASSHE QTTSHSMGSP FLLAGLIGGA VIFVLVVLLS VFCWHMHKKG RYTSQKWKYN RGRRKDDYCE AGTKKDNSIL EMTETSFQIV SLNNDQLLKG DFRLQPIYTP NGGINYTDCH IPNNMRYCNS SVPDLEHCHT