FLRT1_HUMAN » Leucine-rich repeat transmembrane protein FLRT1

FLRT1_HUMAN » Leucine-rich repeat transmembrane protein FLRT1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FLRT1_HUMAN » Leucine-rich repeat transmembrane protein FLRT1 » Fibronectin-like domain-containing leucine-rich transmembrane protein 1;
Hydrophobic Thickness 34.8 ± 2.4 Å
Tilt Angle 3 ± 1°
ΔGtransfer -46.3 kcal/mol
ΔGfold -20.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 523-550 (522-552)
Pathways none
PDB none
OPM none
Complexes none
Interactions

FLRT2, Complex: FLRT2:FLRT1, PubMed

Domains

AA: 25-52, PDBID: 1W8A, Subunit A, Seq Identity:46%, Leucine rich repeat N-terminal domain

AA: 99-161, PDBID: 4V2C, Subunit A, Seq Identity:58%, Leucine rich repeat

AA: 149-206, PDBID: 4LI1, Subunit A, Seq Identity:47%, Leucine rich repeat

AA: 242-301, PDBID: 4V2C, Subunit A, Seq Identity:61%, Leucine rich repeat

UniProt annotation for FLRT1_HUMAN » Leucine-rich repeat transmembrane protein FLRT1
FUNCTION: May have a function in cell adhesion and/or receptor signaling.

TISSUE SPECIFICITY: Expressed in kidney and brain.

UniProt features for FLRT1_HUMAN » Leucine-rich repeat transmembrane protein FLRT1
SIGNAL 1 20 Potential.
CHAIN 21 646 Leucine-rich repeat transmembrane protein FLRT1.
DOMAIN 21 53 LRRNT.
REPEAT 54 75 LRR 1.
REPEAT 79 99 LRR 2.
REPEAT 100 121 LRR 3.
REPEAT 124 145 LRR 4.
REPEAT 150 171 LRR 5.
REPEAT 172 192 LRR 6.
REPEAT 195 218 LRR 7.
REPEAT 221 241 LRR 8.
REPEAT 243 264 LRR 9.
REPEAT 267 288 LRR 10.
DOMAIN 300 352 LRRCT.
DOMAIN 406 501 Fibronectin type-III.
Amino Acid Sequence for FLRT1_HUMAN » Leucine-rich repeat transmembrane protein FLRT1
MDLRDWLFLC YGLIAFLTEV IDSTTCPSVC RCDNGFIYCN DRGLTSIPAD IPDDATTLYL QNNQINNAGI PQDLKTKVNV QVIYLYENDL DEFPINLPRS LRELHLQDNN VRTIARDSLA RIPLLEKLHL DDNSVSTVSI EEDAFADSKQ LKLLFLSRNH LSSIPSGLPH TLEELRLDDN RISTIPLHAF KGLNSLRRLV LDGNLLANQR IADDTFSRLQ NLTELSLVRN SLAAPPLNLP SAHLQKLYLQ DNAISHIPYN TLAKMRELER LDLSNNNLTT LPRGLFDDLG NLAQLLLRNN PWFCGCNLMW LRDWVKARAA VVNVRGLMCQ GPEKVRGMAI KDITSEMDEC FETGPQGGVA NAAAKTTASN HASATTPQGS LFTLKAKRPG LRLPDSNIDY PMATGDGAKT LAIHVKALTA DSIRITWKAT LPASSFRLSW LRLGHSPAVG SITETLVQGD KTEYLLTALE PKSTYIICMV TMETSNAYVA DETPVCAKAE TADSYGPTTT LNQEQNAGPM ASLPLAGIIG GAVALVFLFL VLGAICWYVH QAGELLTRER AYNRGSRKKD DYMESGTKKD NSILEIRGPG LQMLPINPYR AKEEYVVHTI FPSNGSSLCK ATHTIGYGTT RGYRDGGIPD IDYSYT