FGRL1_HUMAN » Fibroblast growth factor receptor-like 1

FGRL1_HUMAN » Fibroblast growth factor receptor-like 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FGRL1_HUMAN » Fibroblast growth factor receptor-like 1 » FGF receptor-like protein 1; FGF homologous factor receptor;FGFR-like protein;Fibroblast growth factor receptor 5;FGFR-5;
Hydrophobic Thickness 35.2 ± 1.8 Å
Tilt Angle 1 ± 1°
ΔGtransfer -40.1 kcal/mol
ΔGfold -12.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 376-400 (376-403)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 29-116, PDBID: 1CS6, Subunit A, Seq Identity:35%, Immunoglobulin I-set domain

AA: 147-238, PDBID: 1CVS, Subunit D, Seq Identity:35%, Immunoglobulin I-set domain

AA: 245-342, PDBID: 1RY7, Subunit B, Seq Identity:25%, Immunoglobulin domain

UniProt annotation for FGRL1_HUMAN » Fibroblast growth factor receptor-like 1
FUNCTION: Has a negative effect on cell proliferation.

SUBUNIT: Interacts with FGF2 with a low affinity.

TISSUE SPECIFICITY: Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.

UniProt features for FGRL1_HUMAN » Fibroblast growth factor receptor-like 1
SIGNAL 1 24
CHAIN 25 504 Fibroblast growth factor receptor-like 1.
DOMAIN 29 115 Ig-like C2-type 1.
DOMAIN 147 237 Ig-like C2-type 2.
DOMAIN 246 354 Ig-like C2-type 3.
DISULFID 51 99 By similarity.
DISULFID 172 221 By similarity.
DISULFID 268 338 By similarity.
Amino Acid Sequence for FGRL1_HUMAN » Fibroblast growth factor receptor-like 1
MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ CPVEGDPPPL TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK ATNGFGSLSV NYTLVVLDDI SPGKESLGPD SSSGGQEDPA SQQWARPRFT QPSKMRRRVI ARPVGSSVRL KCVASGHPRP DITWMKDDQA LTRPEAAEPR KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ RTRSKPVLTG THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS AFLTVLPDPK PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ AQKKPCTPAP APPLPGHRPP GTARDRSGDK DLPSLAALSA GPGVGLCEEH GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT HTHTHSHTHS HVEGKVHQHI HYQC