FERON_ARATH » Receptor-like protein kinase FERONIA

FERON_ARATH » Receptor-like protein kinase FERONIA
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FERON_ARATH » Receptor-like protein kinase FERONIA » Protein SIRENE;
Hydrophobic Thickness 31.2 ± 1.4 Å
Tilt Angle 0 ± 3°
ΔGtransfer -39.5 kcal/mol
ΔGfold -19.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 449-471 (445-475)
Pathways

Adherens junction (KEGG)

PDB none
OPM none
Complexes none
Interactions

BRL3, Complex: BRL3:FERON

Domains

AA: 38-409, Carbohydrate-binding protein of the ER

AA: 536-807, PDBID: 1FMK, Subunit A, Seq Identity:38%, Protein tyrosine kinase

UniProt annotation for FERON_ARATH » Receptor-like protein kinase FERONIA
FUNCTION: Receptor-like protein kinase that mediates the female control of male gamete delivery during fertilization, including growth cessation of compatible pollen tubes ensuring a reproductive isolation barriers, by regulating MLO7 subcellular polarization upon pollen tube perception in the female gametophyte synergids. Required for cell elongation during vegetative growth, mostly in a brassinosteroids- (BR-) independent manner. Acts as an upstream regulator for the Rac/Rop-signaling pathway that controls ROS-mediated root hair development. Seems to regulates a cross- talk between brassinosteroids and ethylene signaling pathways during hypocotyl elongation. Negative regulator of brassinosteroid response in light-grown hypocotyls, but required for brassinosteroid response in etiolated seedlings. Mediates sensitivity to powdery mildew (e.g. Golovinomyces orontii). Positive regulator of auxin-promoted growth that represses the abscisic acid (ABA) signaling via the activation of ABI2 phosphatase. Required for RALF1-mediated extracellular alkalinization in a signaling pathway preventing cell expansion.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBUNIT: Interacts with ROPGEF1. Interacts with RALF1; triggering phosphorylation status and subsequent activation.

TISSUE SPECIFICITY: Expressed in leaves, buds, flowers, siliques, young ovules primordia, and young anthers with immature pollen, but not detected in mature pollen. Highest expression in the synergid cells of the female gametophyte.

DEVELOPMENTAL STAGE: Detected in floral apices, young ovule primordia, and young anthers with immature pollen, but not in older anthers with mature pollen. After fertilization, expressed in globular embryos.

INDUCTION: By brassinosteroids (BR).

MISCELLANEOUS: Female paralog of ANXUR, a male factor expressed in pollen tube that controls release of the sperm cell.

MISCELLANEOUS: Named after the Etruscan goddess of fertility Feronia.

MISCELLANEOUS: "Sirene" means siren in French.

UniProt features for FERON_ARATH » Receptor-like protein kinase FERONIA
SIGNAL 1 27 Potential.
CHAIN 28 895 Receptor-like protein kinase FERONIA.
DOMAIN 536 810 Protein kinase.
ACT_SITE 661 661 Proton acceptor (By similarity).
Amino Acid Sequence for FERON_ARATH » Receptor-like protein kinase FERONIA
MKITEGRFRL SLLLLLLLIS AATLISAADY SPTEKILLNC GGGASNLTDT DNRIWISDVK SKFLSSSSED SKTSPALTQD PSVPEVPYMT ARVFRSPFTY TFPVASGRKF VRLYFYPNSY DGLNATNSLF SVSFGPYTLL KNFSASQTAE ALTYAFIIKE FVVNVEGGTL NMTFTPESAP SNAYAFVNGI EVTSMPDMYS STDGTLTMVG SSGSVTIDNS TALENVYRLN VGGNDISPSA DTGLYRSWYD DQPYIFGAGL GIPETADPNM TIKYPTGTPT YVAPVDVYST ARSMGPTAQI NLNYNLTWIF SIDSGFTYLV RLHFCEVSSN ITKINQRVFT IYLNNQTAEP EADVIAWTSS NGVPFHKDYV VNPPEGNGQQ DLWLALHPNP VNKPEYYDSL LNGVEIFKMN TSDGNLAGTN PIPGPQVTAD PSKVLRPTTR KSKSNTAIIA GAASGAVVLA LIIGFCVFGA YRRRKRGDYQ PASDATSGWL PLSLYGNSHS AGSAKTNTTG SYASSLPSNL CRHFSFAEIK AATKNFDESR VLGVGGFGKV YRGEIDGGTT KVAIKRGNPM SEQGVHEFQT EIEMLSKLRH RHLVSLIGYC EENCEMILVY DYMAHGTMRE HLYKTQNPSL PWKQRLEICI GAARGLHYLH TGAKHTIIHR DVKTTNILLD EKWVAKVSDF GLSKTGPTLD HTHVSTVVKG SFGYLDPEYF RRQQLTEKSD VYSFGVVLFE ALCARPALNP TLAKEQVSLA EWAPYCYKKG MLDQIVDPYL KGKITPECFK KFAETAMKCV LDQGIERPSM GDVLWNLEFA LQLQESAEEN GKGVCGDMDM DEIKYDDGNC KGKNDKSSDV YEGNVTDSRS SGIDMSIGGR SLASEDSDGL TPSAVFSQIM NPKGR