FCRL6_HUMAN » Fc receptor-like protein 6

FCRL6_HUMAN » Fc receptor-like protein 6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCRL6_HUMAN » Fc receptor-like protein 6 » FcR-like protein 6; FcRL6; Fc receptor homolog 6;FcRH6; IFGP6;
Hydrophobic Thickness 30.6 ± 2.1 Å
Tilt Angle 4 ± 2°
ΔGtransfer -24.0 kcal/mol
ΔGfold -15.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 311-331 (311-336)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 19-105, PDBID: 4W4O, Subunit C, Seq Identity:35%, Immunoglobulin domain

AA: 111-200, PDBID: 4HWN, Subunit A, Seq Identity:39%, Immunoglobulin domain

AA: 206-280, PDBID: 3K0W, Subunit A, Seq Identity:29%, Immunoglobulin domain

UniProt annotation for FCRL6_HUMAN » Fc receptor-like protein 6
SUBUNIT: Interacts with PTPN11.

TISSUE SPECIFICITY: Expressed by cytolytic cells including NK cells, effector and effector-memory CD8+ T-cells. Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8+ T-cells but also populations of CD4+ T-cells.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.

UniProt features for FCRL6_HUMAN » Fc receptor-like protein 6
SIGNAL 1 19 Potential.
CHAIN 20 434 Fc receptor-like protein 6.
DOMAIN 20 95 Ig-like C2-type 1.
DOMAIN 111 197 Ig-like C2-type 2.
DOMAIN 207 293 Ig-like C2-type 3.
MOTIF 369 374 ITIM motif.
DISULFID 39 83 By similarity.
DISULFID 132 180 By similarity.
DISULFID 228 276 By similarity.
Amino Acid Sequence for FCRL6_HUMAN » Fc receptor-like protein 6
MLLWTAVLLF VPCVGKTVWL YLQAWPNPVF EGDALTLRCQ GWKNTPLSQV KFYRDGKFLH FSKENQTLSM GAATVQSRGQ YSCSGQVMYI PQTFTQTSET AMVQVQELFP PPVLSAIPSP EPREGSLVTL RCQTKLHPLR SALRLLFSFH KDGHTLQDRG PHPELCIPGA KEGDSGLYWC EVAPEGGQVQ KQSPQLEVRV QAPVSRPVLT LHHGPADPAV GDMVQLLCEA QRGSPPILYS FYLDEKIVGN HSAPCGGTTS LLFPVKSEQD AGNYSCEAEN SVSRERSEPK KLSLKGSQVL FTPASNWLVP WLPASLLGLM VIAAALLVYV RSWRKAGPLP SQIPPTAPGG EQCPLYANVH HQKGKDEGVV YSVVHRTSKR SEARSAEFTV GRKDSSIICA EVRCLQPSEV SSTEVNMRSR TLQEPLSDCE EVLC