FCRL5_HUMAN » Fc receptor-like protein 5

FCRL5_HUMAN » Fc receptor-like protein 5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCRL5_HUMAN » Fc receptor-like protein 5 » FcR-like protein 5; FcRL5; BXMAS1;Fc receptor homolog 5;FcRH5; Immune receptor translocation-associated protein 2;
Hydrophobic Thickness 37.6 ± 2.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -43.0 kcal/mol
ΔGfold -13.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 848-873 (847-877)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 22-100, PDBID: 3AY4, Subunit C, Seq Identity:30%, Immunoglobulin domain

AA: 104-185, PDBID: 1E4J, Subunit A, Seq Identity:38%, Immunoglobulin domain

AA: 286-373, PDBID: 2ENS, Subunit A, Seq Identity:26%, Immunoglobulin domain

AA: 379-466, PDBID: 2ENS, Subunit A, Seq Identity:26%, Immunoglobulin domain

AA: 472-559, PDBID: 2ENS, Subunit A, Seq Identity:26%, Immunoglobulin domain

AA: 565-652, PDBID: 1FCG, Subunit A, Seq Identity:23%, Immunoglobulin domain

AA: 751-837, PDBID: 2ENS, Subunit A, Seq Identity:26%, Immunoglobulin domain

UniProt annotation for FCRL5_HUMAN » Fc receptor-like protein 5
FUNCTION: May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.

TISSUE SPECIFICITY: Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).

DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).

DISEASE: Note=A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32).

UniProt features for FCRL5_HUMAN » Fc receptor-like protein 5
SIGNAL 1 15 Potential.
CHAIN 16 977 Fc receptor-like protein 5.
DOMAIN 23 101 Ig-like C2-type 1.
DOMAIN 188 271 Ig-like C2-type 2.
DOMAIN 287 374 Ig-like C2-type 3.
DOMAIN 380 463 Ig-like C2-type 4.
DOMAIN 473 556 Ig-like C2-type 5.
DOMAIN 566 651 Ig-like C2-type 6.
DOMAIN 659 744 Ig-like C2-type 7.
DOMAIN 752 834 Ig-like C2-type 8.
MOTIF 897 902 ITIM motif 1.
MOTIF 910 915 ITIM motif 2.
MOTIF 922 927 ITIM motif 3.
MOTIF 952 957 ITIM motif 4.
DISULFID 44 85 By similarity.
DISULFID 211 260 By similarity.
DISULFID 308 355 By similarity.
DISULFID 401 448 By similarity.
DISULFID 494 541 By similarity.
DISULFID 587 634 By similarity.
DISULFID 680 727 By similarity.
DISULFID 773 819 By similarity.
Amino Acid Sequence for FCRL5_HUMAN » Fc receptor-like protein 5
MLLWVILLVL APVSGQFART PRPIIFLQPP WTTVFQGERV TLTCKGFRFY SPQKTKWYHR YLGKEILRET PDNILEVQES GEYRCQAQGS PLSSPVHLDF SSASLILQAP LSVFEGDSVV LRCRAKAEVT LNNTIYKNDN VLAFLNKRTD FHIPHACLKD NGAYRCTGYK ESCCPVSSNT VKIQVQEPFT RPVLRASSFQ PISGNPVTLT CETQLSLERS DVPLRFRFFR DDQTLGLGWS LSPNFQITAM WSKDSGFYWC KAATMPHSVI SDSPRSWIQV QIPASHPVLT LSPEKALNFE GTKVTLHCET QEDSLRTLYR FYHEGVPLRH KSVRCERGAS ISFSLTTENS GNYYCTADNG LGAKPSKAVS LSVTVPVSHP VLNLSSPEDL IFEGAKVTLH CEAQRGSLPI LYQFHHEDAA LERRSANSAG GVAISFSLTA EHSGNYYCTA DNGFGPQRSK AVSLSITVPV SHPVLTLSSA EALTFEGATV TLHCEVQRGS PQILYQFYHE DMPLWSSSTP SVGRVSFSFS LTEGHSGNYY CTADNGFGPQ RSEVVSLFVT VPVSRPILTL RVPRAQAVVG DLLELHCEAP RGSPPILYWF YHEDVTLGSS SAPSGGEASF NLSLTAEHSG NYSCEANNGL VAQHSDTISL SVIVPVSRPI LTFRAPRAQA VVGDLLELHC EALRGSSPIL YWFYHEDVTL GKISAPSGGG ASFNLSLTTE HSGIYSCEAD NGLEAQRSEM VTLKVAVPVS RPVLTLRAPG THAAVGDLLE LHCEALRGSP LILYRFFHED VTLGNRSSPS GGASLNLSLT AEHSGNYSCE ADNGLGAQRS ETVTLYITGL TANRSGPFAT GVAGGLLSIA GLAAGALLLY CWLSRKAGRK PASDPARSPS DSDSQEPTYH NVPAWEELQP VYTNANPRGE NVVYSEVRII QEKKKHAVAS DPRHLRNKGS PIIYSEVKVA STPVSGSLFL ASSAPHR