FCRL4_HUMAN » Fc receptor-like protein 4

FCRL4_HUMAN » Fc receptor-like protein 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCRL4_HUMAN » Fc receptor-like protein 4 » FcR-like protein 4; FcRL4; Fc receptor homolog 4;FcRH4; IFGP family protein 2;hIFGP2; Immune receptor translocation-associated protein 1;
Hydrophobic Thickness 33.2 ± 2.0 Å
Tilt Angle 0 ± 4°
ΔGtransfer -48.5 kcal/mol
ΔGfold -18.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 387-411 (384-416)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 104-184, PDBID: 4W4O, Subunit C, Seq Identity:32%, Immunoglobulin domain

AA: 294-372, PDBID: 2NPL, Subunit X, Seq Identity:31%, Immunoglobulin domain

UniProt annotation for FCRL4_HUMAN » Fc receptor-like protein 4
FUNCTION: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.

TISSUE SPECIFICITY: Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).

DISEASE: Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).

DISEASE: Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

UniProt features for FCRL4_HUMAN » Fc receptor-like protein 4
SIGNAL 1 19 Potential.
CHAIN 20 515 Fc receptor-like protein 4.
DOMAIN 23 97 Ig-like C2-type 1.
DOMAIN 102 183 Ig-like C2-type 2.
DOMAIN 193 271 Ig-like C2-type 3.
DOMAIN 275 374 Ig-like C2-type 4.
MOTIF 449 454 ITIM motif 1.
MOTIF 461 466 ITIM motif 2.
MOTIF 491 496 ITIM motif 3.
SITE 17 18 Breakpoint for insertion to form FCRL4- IGHA1 fusion protein.
DISULFID 44 85 By similarity.
DISULFID 123 167 By similarity.
DISULFID 212 261 By similarity.
DISULFID 310 359 By similarity.
Amino Acid Sequence for FCRL4_HUMAN » Fc receptor-like protein 4
MLLWASLLAF APVCGQSAAA HKPVISVHPP WTTFFKGERV TLTCNGFQFY ATEKTTWYHR HYWGEKLTLT PGNTLEVRES GLYRCQARGS PRSNPVRLLF SSDSLILQAP YSVFEGDTLV LRCHRRRKEK LTAVKYTWNG NILSISNKSW DLLIPQASSN NNGNYRCIGY GDENDVFRSN FKIIKIQELF PHPELKATDS QPTEGNSVNL SCETQLPPER SDTPLHFNFF RDGEVILSDW STYPELQLPT VWRENSGSYW CGAETVRGNI HKHSPSLQIH VQRIPVSGVL LETQPSGGQA VEGEMLVLVC SVAEGTGDTT FSWHREDMQE SLGRKTQRSL RAELELPAIR QSHAGGYYCT ADNSYGPVQS MVLNVTVRET PGNRDGLVAA GATGGLLSAL LLAVALLFHC WRRRKSGVGF LGDETRLPPA PGPGESSHSI CPAQVELQSL YVDVHPKKGD LVYSEIQTTQ LGEEEEANTS RTLLEDKDVS VVYSEVKTQH PDNSAGKISS KDEES