FCRL3_HUMAN » Fc receptor-like protein 3

FCRL3_HUMAN » Fc receptor-like protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCRL3_HUMAN » Fc receptor-like protein 3 » FcR-like protein 3; FcRL3; Fc receptor homolog 3;FcRH3; IFGP family protein 3;hIFGP3; Immune receptor translocation-associated protein 3;SH2 domain-containing phosphatase anchor protein 2;
Hydrophobic Thickness 37.2 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -41.2 kcal/mol
ΔGfold -23.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 573-597 (569-601)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 101-185, PDBID: 1F2Q, Subunit A, Seq Identity:28%, Immunoglobulin domain

AA: 191-280, PDBID: 4HWN, Subunit A, Seq Identity:26%, Immunoglobulin domain

AA: 292-370, PDBID: 4LL9, Subunit C, Seq Identity:33%, Immunoglobulin domain

AA: 382-471, PDBID: 2ENS, Subunit A, Seq Identity:23%, Immunoglobulin domain

AA: 475-562, PDBID: 1FCG, Subunit A, Seq Identity:24%, Immunoglobulin domain

UniProt annotation for FCRL3_HUMAN » Fc receptor-like protein 3
SUBUNIT: Interacts with PTPN6, PTPN11, SYK and ZAP70.

TISSUE SPECIFICITY: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at protein level).

DISEASE: Rheumatoid arthritis (RA) OMIM: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

DISEASE: Note=Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.

UniProt features for FCRL3_HUMAN » Fc receptor-like protein 3
SIGNAL 1 17 Potential.
CHAIN 18 734 Fc receptor-like protein 3.
DOMAIN 21 98 Ig-like C2-type 1.
DOMAIN 99 182 Ig-like C2-type 2.
DOMAIN 192 270 Ig-like C2-type 3.
DOMAIN 284 369 Ig-like C2-type 4.
DOMAIN 383 470 Ig-like C2-type 5.
DOMAIN 476 563 Ig-like C2-type 6.
MOTIF 648 653 ITIM motif 1.
MOTIF 660 665 ITIM motif 2.
MOTIF 690 695 ITIM motif 3.
MOTIF 720 725 ITIM motif 4.
DISULFID 44 82 By similarity.
DISULFID 120 163 By similarity.
DISULFID 211 260 By similarity.
DISULFID 309 358 By similarity.
DISULFID 404 451 By similarity.
DISULFID 497 544 By similarity.
Amino Acid Sequence for FCRL3_HUMAN » Fc receptor-like protein 3
MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQELFL HPVLRASSST PIEGSPMTLT CETQLSPQRP DVQLQFSLFR DSQTLGLGWS RSPRLQIPAM WTEDSGSYWC EVETVTHSIK KRSLRSQIRV QRVPVSNVNL EIRPTGGQLI EGENMVLICS VAQGSGTVTF SWHKEGRVRS LGRKTQRSLL AELHVLTVKE SDAGRYYCAA DNVHSPILST WIRVTVRIPV SHPVLTFRAP RAHTVVGDLL ELHCESLRGS PPILYRFYHE DVTLGNSSAP SGGGASFNLS LTAEHSGNYS CDADNGLGAQ HSHGVSLRVT VPVSRPVLTL RAPGAQAVVG DLLELHCESL RGSFPILYWF YHEDDTLGNI SAHSGGGASF NLSLTTEHSG NYSCEADNGL GAQHSKVVTL NVTGTSRNRT GLTAAGITGL VLSILVLAAA AALLHYARAR RKPGGLSATG TSSHSPSECQ EPSSSRPSRI DPQEPTHSKP LAPMELEPMY SNVNPGDSNP IYSQIWSIQH TKENSANCPM MHQEHEELTV LYSELKKTHP DDSAGEASSR GRAHEEDDEE NYENVPRVLL ASDH