FCRL2_HUMAN » Fc receptor-like protein 2

FCRL2_HUMAN » Fc receptor-like protein 2
Magnify FCRL2_HUMAN » Fc receptor-like protein 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCRL2_HUMAN » Fc receptor-like protein 2 » FcR-like protein 2; FcRL2; Fc receptor homolog 2;FcRH2; IFGP family protein 4;Immunoglobulin receptor translocation-associated protein 4;SH2 domain-containing phosphatase anchor protein 1;
Hydrophobic Thickness 38.4 ± 2.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -47.8 kcal/mol
ΔGfold -20.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 397-422 (389-426)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 19-102, PDBID: 1E4J, Subunit A, Seq Identity:31%, Immunoglobulin domain

AA: 206-293, PDBID: 1F2Q, Subunit A, Seq Identity:22%, Immunoglobulin domain

AA: 299-386, PDBID: 2ENS, Subunit A, Seq Identity:27%, Immunoglobulin domain

UniProt annotation for FCRL2_HUMAN » Fc receptor-like protein 2
FUNCTION: May have an regulatory role in normal and neoplastic B cell development.

SUBUNIT: The tyrosine-phosphorylated isoform 2 interacts with PTPN6.

TISSUE SPECIFICITY: Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B- cell lines. Preferentially expressed in memory B-cells (at protein level).

DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6.

UniProt features for FCRL2_HUMAN » Fc receptor-like protein 2
SIGNAL 1 19
CHAIN 20 508 Fc receptor-like protein 2.
DOMAIN 20 98 Ig-like C2-type 1.
DOMAIN 109 187 Ig-like C2-type 2.
DOMAIN 201 290 Ig-like C2-type 3.
DOMAIN 300 387 Ig-like C2-type 4.
MOTIF 446 451 ITIM motif 1.
MOTIF 460 465 ITIM motif 2.
MOTIF 472 477 ITIM motif 3.
MOTIF 500 505 ITIM motif 4.
DISULFID 128 177 By similarity.
DISULFID 226 275 By similarity.
DISULFID 321 368 By similarity.
Amino Acid Sequence for FCRL2_HUMAN » Fc receptor-like protein 2
MLLWSLLVIF DAVTEQADSL TLVAPSSVFE GDSIVLKCQG EQNWKIQKMA YHKDNKELSV FKKFSDFLIQ SAVLSDSGNY FCSTKGQLFL WDKTSNIVKI KVQELFQRPV LTASSFQPIE GGPVSLKCET RLSPQRLDVQ LQFCFFRENQ VLGSGWSSSP ELQISAVWSE DTGSYWCKAE TVTHRIRKQS LQSQIHVQRI PISNVSLEIR APGGQVTEGQ KLILLCSVAG GTGNVTFSWY REATGTSMGK KTQRSLSAEL EIPAVKESDA GKYYCRADNG HVPIQSKVVN IPVRIPVSRP VLTLRSPGAQ AAVGDLLELH CEALRGSPPI LYQFYHEDVT LGNSSAPSGG GASFNLSLTA EHSGNYSCEA NNGLGAQCSE AVPVSISGPD GYRRDLMTAG VLWGLFGVLG FTGVALLLYA LFHKISGESS ATNEPRGASR PNPQEFTYSS PTPDMEELQP VYVNVGSVDV DVVYSQVWSM QQPESSANIR TLLENKDSQV IYSSVKKS