FCRL1_HUMAN » Fc receptor-like protein 1

FCRL1_HUMAN » Fc receptor-like protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCRL1_HUMAN » Fc receptor-like protein 1 » FcR-like protein 1; FcRL1; Fc receptor homolog 1;FcRH1; IFGP family protein 1;hIFGP1; Immune receptor translocation-associated protein 5;
Hydrophobic Thickness 23.2 ± 2.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -25.2 kcal/mol
ΔGfold -8.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 309-331 (307-339)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 18-105, PDBID: 4W4O, Subunit C, Seq Identity:29%, Immunoglobulin domain

AA: 113-187, PDBID: 3DMK, Subunit B, Seq Identity:28%, Immunoglobulin domain

AA: 207-294, PDBID: 1E4J, Subunit A, Seq Identity:23%, Immunoglobulin domain

UniProt annotation for FCRL1_HUMAN » Fc receptor-like protein 1
FUNCTION: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.

TISSUE SPECIFICITY: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level).

INDUCTION: Down-regulated in activated B-cells.

UniProt features for FCRL1_HUMAN » Fc receptor-like protein 1
SIGNAL 1 16 Potential.
CHAIN 17 429 Fc receptor-like protein 1.
DOMAIN 17 104 Ig-like C2-type 1.
DOMAIN 109 200 Ig-like C2-type 2.
DOMAIN 208 291 Ig-like C2-type 3.
MOTIF 354 359 ITIM motif 1.
MOTIF 367 372 ITIM motif 2.
MOTIF 379 384 ITIM motif 3.
MOTIF 410 415 ITIM motif 4.
MOTIF 423 428 ITIM motif 5.
DISULFID 38 86 By similarity.
DISULFID 134 183 By similarity.
DISULFID 229 276 By similarity.
Amino Acid Sequence for FCRL1_HUMAN » Fc receptor-like protein 1
MLPRLLLLIC APLCEPAELF LIASPSHPTE GSPVTLTCKM PFLQSSDAQF QFCFFRDTRA LGPGWSSSPK LQIAAMWKED TGSYWCEAQT MASKVLRSRR SQINVHRVPV ADVSLETQPP GGQVMEGDRL VLICSVAMGT GDITFLWYKG AVGLNLQSKT QRSLTAEYEI PSVRESDAEQ YYCVAENGYG PSPSGLVSIT VRIPVSRPIL MLRAPRAQAA VEDVLELHCE ALRGSPPILY WFYHEDITLG SRSAPSGGGA SFNLSLTEEH SGNYSCEANN GLGAQRSEAV TLNFTVPTGA RSNHLTSGVI EGLLSTLGPA TVALLFCYGL KRKIGRRSAR DPLRSLPSPL PQEFTYLNSP TPGQLQPIYE NVNVVSGDEV YSLAYYNQPE QESVAAETLG THMEDKVSLD IYSRLRKANI TDVDYEDAM