FCGRN_HUMAN » IgG receptor FcRn large subunit p51

FCGRN_HUMAN » IgG receptor FcRn large subunit p51
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCGRN_HUMAN » IgG receptor FcRn large subunit p51 » FcRn; IgG Fc fragment receptor transporter alpha chain;Neonatal Fc receptor;
Hydrophobic Thickness 42.4 ± 2.4 Å
Tilt Angle 5 ± 3°
ΔGtransfer -25.6 kcal/mol
ΔGfold -21.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 295-324 (291-326)
Pathways none
PDB 3m17 (24-290), 3m1b (24-290), 4n0f (A/E/H/K=27-297), 1exu (A=24-290), 4n0u (A=27-290), 4k71 (B/E=24-297)
OPM none
Complexes none
Interactions none
Domains

AA: 26-197, PDBID: 1EXU, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 204-282, PDBID: 1EXU, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for FCGRN_HUMAN » IgG receptor FcRn large subunit p51
FUNCTION: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.

SUBUNIT: FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I- like heterodimer (By similarity).

UniProt features for FCGRN_HUMAN » IgG receptor FcRn large subunit p51
SIGNAL 1 23
CHAIN 24 365 IgG receptor FcRn large subunit p51.
DOMAIN 202 289 Ig-like C1-type.
REGION 24 110 Alpha-1.
REGION 111 200 Alpha-2.
REGION 201 290 Alpha-3.
REGION 291 297 Connecting peptide.
DISULFID 119 182
DISULFID 221 275
Amino Acid Sequence for FCGRN_HUMAN » IgG receptor FcRn large subunit p51
MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGTGQGDFG PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA QDADLKDVNV IPATA