FCGRC_HUMAN » Putative high affinity immunoglobulin gamma Fc receptor IC

FCGRC_HUMAN » Putative high affinity immunoglobulin gamma Fc receptor IC
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCGRC_HUMAN » Putative high affinity immunoglobulin gamma Fc receptor IC » IgG Fc receptor IC; Fc-gamma RIC;FcRIC; hFcgammaRIC;
Hydrophobic Thickness 34.4 ± 2.2 Å
Tilt Angle 3 ± 2°
ΔGtransfer -43.5 kcal/mol
ΔGfold -17.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 194-219 (194-226)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 23-87, PDBID: 4W4O, Subunit C, Seq Identity:100%, Immunoglobulin domain

AA: 104-186, PDBID: 4W4O, Subunit C, Seq Identity:83%, Immunoglobulin domain

UniProt annotation for FCGRC_HUMAN » Putative high affinity immunoglobulin gamma Fc receptor IC
FUNCTION: May bind to the Fc region of immunoglobulins gamma. May function in the humoral immune response (By similarity).
UniProt features for FCGRC_HUMAN » Putative high affinity immunoglobulin gamma Fc receptor IC
SIGNAL 1 15 Potential.
CHAIN 16 280 Putative high affinity immunoglobulin gamma Fc receptor IC.
DOMAIN 22 101 Ig-like C2-type 1.
DOMAIN 105 182 Ig-like C2-type 2.
DISULFID 43 85 By similarity.
DISULFID 124 168 By similarity.
Amino Acid Sequence for FCGRC_HUMAN » Putative high affinity immunoglobulin gamma Fc receptor IC
MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG SSSTQWFLNG TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI HRGWPLLQVS SRVFTEGEPL ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN SNLTILKTNI SHNGTYHCSG KGKHHYTSAG ISQYTVKGLQ LPTPVWFHVL FYLAVGIMFL VNTVLWVTIR KELKRKKKWN LEISLDSGHE KKVISSLQED RHLEEELKCQ EQKEEQLQEG VHRKEPQGAT