FCGRB_HUMAN » High affinity immunoglobulin gamma Fc receptor IB

FCGRB_HUMAN » High affinity immunoglobulin gamma Fc receptor IB
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCGRB_HUMAN » High affinity immunoglobulin gamma Fc receptor IB » IgG Fc receptor IB; Fc-gamma RIB;FcRIB; hFcgammaRIB;
Hydrophobic Thickness 34.0 ± 1.0 Å
Tilt Angle 43 ± 4°
ΔGtransfer -27.5 kcal/mol
ΔGfold -17.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 194-219 (194-226)
Pathways

Immune System (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 23-87, PDBID: 4W4O, Subunit C, Seq Identity:100%, Immunoglobulin domain

AA: 104-186, PDBID: 4W4O, Subunit C, Seq Identity:92%, Immunoglobulin domain

UniProt annotation for FCGRB_HUMAN » High affinity immunoglobulin gamma Fc receptor IB
FUNCTION: May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.

INDUCTION: Up-regulated by IFNG/IFN-gamma.

UniProt features for FCGRB_HUMAN » High affinity immunoglobulin gamma Fc receptor IB
SIGNAL 1 15 Potential.
CHAIN 16 280 High affinity immunoglobulin gamma Fc receptor IB.
DOMAIN 22 101 Ig-like C2-type 1.
DOMAIN 95 184 Ig-like C2-type 2.
DISULFID 43 85 By similarity.
DISULFID 124 168 By similarity.
Amino Acid Sequence for FCGRB_HUMAN » High affinity immunoglobulin gamma Fc receptor IB
MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG SSSTQWFLNG TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI HRGWLLLQVS SRVFMEGEPL ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN SNLTILKTNI SHNGTYHCSG MGKHRYTSAG ISQYTVKGLQ LPTPVWFHVL FYLAVGIMFL VNTVLWVTIR KELKRKKKWN LEISLDSGHE KKVISSLQED RHLEEELKCQ EQKEEQLQEG VHRKEPQGAT