FCGR1_HUMAN » High affinity immunoglobulin gamma Fc receptor I

FCGR1_HUMAN » High affinity immunoglobulin gamma Fc receptor I
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCGR1_HUMAN » High affinity immunoglobulin gamma Fc receptor I » IgG Fc receptor I; Fc-gamma RI;FcRI; Fc-gamma RIA;FcgammaRIa;
Hydrophobic Thickness 34.0 ± 1.0 Å
Tilt Angle 43 ± 4°
ΔGtransfer -27.5 kcal/mol
ΔGfold -17.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 288-313 (288-320)
Pathways

Fc gamma R-mediated phagocytosis (KEGG)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

Leishmaniasis (KEGG)

Osteoclast differentiation (KEGG)

Phagosome (KEGG)

Staphylococcus aureus infection (KEGG)

Systemic lupus erythematosus (KEGG)

Transcriptional misregulation in cancer (KEGG)

Tuberculosis (KEGG)

PDB 3rjd (21-282)
OPM none
Complexes none
Interactions

FCAR, Complex: FCAR:FCGR1, PubMed

FCG3A, Complex: FCGR1:FCG3A, PubMed

LAT, Complex: FCGR1:LAT, PubMed

LAT, Complex: LAT:PLCG2:KSYK:FCGR1

LIRB2, Complex: FCGR1:LIRB2, PubMed

Domains

AA: 23-87, PDBID: 4W4O, Subunit C, Seq Identity:100%, Immunoglobulin domain

AA: 104-185, PDBID: 4W4O, Subunit C, Seq Identity:100%, Immunoglobulin domain

AA: 195-275, PDBID: 4W4O, Subunit C, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for FCGR1_HUMAN » High affinity immunoglobulin gamma Fc receptor I
FUNCTION: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

SUBUNIT: Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.

TISSUE SPECIFICITY: Monocyte/macrophage specific.

UniProt features for FCGR1_HUMAN » High affinity immunoglobulin gamma Fc receptor I
SIGNAL 1 15
CHAIN 16 374 High affinity immunoglobulin gamma Fc receptor I.
DOMAIN 22 101 Ig-like C2-type 1.
DOMAIN 95 184 Ig-like C2-type 2.
DOMAIN 190 277 Ig-like C2-type 3.
REGION 312 332 Interaction with EPB41L2.
DISULFID 43 85 By similarity.
DISULFID 124 168 By similarity.
DISULFID 212 260 By similarity.
Amino Acid Sequence for FCGR1_HUMAN » High affinity immunoglobulin gamma Fc receptor I
MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG SSSTQWFLNG TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI HRGWLLLQVS SRVFTEGEPL ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN SNLTILKTNI SHNGTYHCSG MGKHRYTSAG ISVTVKELFP APVLNASVTS PLLEGNLVTL SCETKLLLQR PGLQLYFSFY MGSKTLRGRN TSSEYQILTA RREDSGLYWC EAATEDGNVL KRSPELELQV LGLQLPTPVW FHVLFYLAVG IMFLVNTVLW VTIRKELKRK KKWDLEISLD SGHEKKVISS LQEDRHLEEE LKCQEQKEEQ LQEGVHRKEP QGAT