FCG3A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor III-A

FCG3A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor III-A
Magnify FCG3A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor III-AEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCG3A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor III-A » IgG Fc receptor III-2;Fc-gamma RIII-alpha;Fc-gamma RIIIa; FcRIIIa; Fc-gamma RIII; FcRIII; FcR-10;CD16a antigen;
Hydrophobic Thickness 34.4 ± 2.2 Å
Tilt Angle 2 ± 2°
ΔGtransfer -24.2 kcal/mol
ΔGfold -9.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 206-229 (206-230)
Pathways

Fc gamma R-mediated phagocytosis (KEGG)

Immune System (Reactome)

Leishmaniasis (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

Osteoclast differentiation (KEGG)

Phagosome (KEGG)

Staphylococcus aureus infection (KEGG)

Systemic lupus erythematosus (KEGG)

Tuberculosis (KEGG)

PDB 3wn5 (C/F=18-208), 3sgj (C=19-208), 3sgk (C=19-208), 3ay4 (C=21-193)
OPM none
Complexes none
Interactions

A4, Complex: FCG3A:A4, PubMed

CD38, Complex: CD38:FCG3A, PubMed

CD3Z, Complex: FCG3A:CD3Z, PubMed

CD4, Complex: FCG3A:CD4, PubMed

FCERG, Complex: FCERG:FCG3A, PubMed

FCGR1, Complex: FCGR1:FCG3A, PubMed

GPVI, Complex: FCG3A:GPVI, PubMed

PTPRC, Complex: PTPRC:FCG3A, PubMed

Domains

AA: 27-104, PDBID: 3AY4, Subunit C, Seq Identity:100%, Immunoglobulin domain

AA: 108-190, PDBID: 3AY4, Subunit C, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for FCG3A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor III-A
FUNCTION: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

SUBUNIT: Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1 (By similarity).

TISSUE SPECIFICITY: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.

DISEASE: Immunodeficiency 20 (IMD20) OMIM: A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV). Note=The disease is caused by mutations affecting the gene represented in this entry.

MISCELLANEOUS: Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue- specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the "Ser-203" in III-B determines the GPI- anchoring.

UniProt features for FCG3A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor III-A
SIGNAL 1 16 Potential.
CHAIN 17 254 Low affinity immunoglobulin gamma Fc region receptor III-A.
DOMAIN 24 105 Ig-like C2-type 1.
DOMAIN 107 189 Ig-like C2-type 2.
DISULFID 47 89 By similarity.
DISULFID 128 172 By similarity.
Amino Acid Sequence for FCG3A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor III-A
MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN VSSETVNITI TQGLAVSTIS SFFPPGYQVS FCLVMVLLFA VDTGLYFSVK TNIRSSTRDW KDHKFKWRKD PQDK