FCG2C_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-c

FCG2C_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-c
Magnify FCG2C_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-cEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCG2C_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-c » IgG Fc receptor II-c; CDw32;Fc-gamma RII-c;Fc-gamma-RIIc; FcRII-c;
Hydrophobic Thickness 36.4 ± 1.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -47.7 kcal/mol
ΔGfold -25.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 221-248 (221-250)
Pathways

Leishmaniasis (KEGG)

Osteoclast differentiation (KEGG)

Phagosome (KEGG)

Staphylococcus aureus infection (KEGG)

Tuberculosis (KEGG)

PDB 3wjl (C=45-217)
OPM none
Complexes none
Interactions

ITA4, Complex: FCG2C:ITA4, PubMed

Domains

AA: 49-128, PDBID: 2FCB, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 132-214, PDBID: 2FCB, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for FCG2C_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-c
FUNCTION: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

TISSUE SPECIFICITY: Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.

DOMAIN: Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation.

UniProt features for FCG2C_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-c
SIGNAL 1 42 Potential.
CHAIN 43 323 Low affinity immunoglobulin gamma Fc region receptor II-c.
DOMAIN 48 127 Ig-like C2-type 1.
DOMAIN 131 213 Ig-like C2-type 2.
DISULFID 71 113 By similarity.
DISULFID 152 196 By similarity.
Amino Acid Sequence for FCG2C_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-c
MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA VVALIYCRKK RISANSTDPV KAAQFEPPGR QMIAIRKRQP EETNNDYETA DGGYMTLNPR APTDDDKNIY LTLPPNDHVN SNN