FCG2B_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-b

FCG2B_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-b
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCG2B_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-b » IgG Fc receptor II-b; CDw32;Fc-gamma RII-b;Fc-gamma-RIIb; FcRII-b;
Hydrophobic Thickness 36.4 ± 1.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -47.7 kcal/mol
ΔGfold -25.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 221-248 (221-250)
Pathways

B cell receptor signaling pathway (KEGG)

Fc gamma R-mediated phagocytosis (KEGG)

Immune System (Reactome)

Measles (KEGG)

Osteoclast differentiation (KEGG)

Phagosome (KEGG)

Staphylococcus aureus infection (KEGG)

Tuberculosis (KEGG)

PDB 2fcb (46-217), 3wjj (C=45-217)
OPM none
Complexes none
Interactions none
Domains

AA: 49-128, PDBID: 2FCB, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 132-214, PDBID: 2FCB, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for FCG2B_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-b
FUNCTION: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

SUBUNIT: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN.

TISSUE SPECIFICITY: Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

DISEASE: Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.

DISEASE: Systemic lupus erythematosus (SLE) OMIM: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. associated with variations affecting the gene represented in this entry.

UniProt features for FCG2B_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-b
SIGNAL 1 42 Potential.
CHAIN 43 310 Low affinity immunoglobulin gamma Fc region receptor II-b.
DOMAIN 48 127 Ig-like C2-type 1.
DOMAIN 131 213 Ig-like C2-type 2.
MOTIF 290 295 ITIM motif.
DISULFID 71 113
DISULFID 152 196
Amino Acid Sequence for FCG2B_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-b
MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA VVALIYCRKK RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA LEEPDDQNRI