FCG2A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-a

FCG2A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-a
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCG2A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-a » IgG Fc receptor II-a; CDw32;Fc-gamma RII-a;Fc-gamma-RIIa; FcRII-a;
Hydrophobic Thickness 37.2 ± 1.4 Å
Tilt Angle 1 ± 3°
ΔGtransfer -55.3 kcal/mol
ΔGfold -27.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 215-243 (215-244)
Pathways

Fc gamma R-mediated phagocytosis (KEGG)

Immune System (Reactome)

Leishmaniasis (KEGG)

Osteoclast differentiation (KEGG)

Phagosome (KEGG)

Staphylococcus aureus infection (KEGG)

Systemic lupus erythematosus (KEGG)

Tuberculosis (KEGG)

PDB 3ry4 (37-206), 3ry5 (37-206), 1h9v (37-208), 1fcg (A=34-207), 3ry6 (C=40-206), 3d5o (F=37-207)
OPM none
Complexes none
Interactions

GPVI, Complex: GPVI:FCG2A, PubMed

ITA4, Complex: FCG2A:ITA4, PubMed

LAT, Complex: FCG2A:LAT, PubMed

Domains

AA: 40-119, PDBID: 1FCG, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 123-205, PDBID: 1FCG, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for FCG2A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-a
FUNCTION: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

SUBUNIT: Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.

TISSUE SPECIFICITY: Found on monocytes, neutrophils and eosinophil platelets.

UniProt features for FCG2A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-a
SIGNAL 1 33
CHAIN 34 317 Low affinity immunoglobulin gamma Fc region receptor II-a.
DOMAIN 39 118 Ig-like C2-type 1.
DOMAIN 122 204 Ig-like C2-type 2.
DISULFID 62 104
DISULFID 143 187
Amino Acid Sequence for FCG2A_HUMAN » Low affinity immunoglobulin gamma Fc region receptor II-a
MTMETQMSQN VCPRNLWLLQ PLTVLLLLAS ADSQAAAPPK AVLKLEPPWI NVLQEDSVTL TCQGARSPES DSIQWFHNGN LIPTHTQPSY RFKANNNDSG EYTCQTGQTS LSDPVHLTVL SEWLVLQTPH LEFQEGETIM LRCHSWKDKP LVKVTFFQNG KSQKFSHLDP TFSIPQANHS HSGDYHCTGN IGYTLFSSKP VTITVQVPSM GSSSPMGIIV AVVIATAVAA IVAAVVALIY CRKKRISANS TDPVKAAQFE PPGRQMIAIR KRQLEETNND YETADGGYMT LNPRAPTDDD KNIYLTLPPN DHVNSNN