FCERG_HUMAN » High affinity immunoglobulin epsilon receptor subunit gamma

FCERG_HUMAN » High affinity immunoglobulin epsilon receptor subunit gamma
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Topology in Plasma membrane
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FCERG_HUMAN » High affinity immunoglobulin epsilon receptor subunit gamma » Fc receptor gamma-chain;FcRgamma; Fc-epsilon RI-gamma;IgE Fc receptor subunit gamma;FceRI gamma;
Hydrophobic Thickness 32.0 ± 2.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -32.2 kcal/mol
ΔGfold -14.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 21-46 (21-53)
Pathways

Asthma (KEGG)

Fc epsilon RI signaling pathway (KEGG)

Hemostasis (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Tuberculosis (KEGG)

PDB none
OPM none
Complexes none
Interactions

CLC4C, Complex: CLC4C:FCERG, PubMed

FCERA, Complex: FCERA:FCERG, PubMed

FCG3A, Complex: FCERG:FCG3A, PubMed

GPVI, Complex: FCERG:GPVI, PubMed

IL3RB, Complex: FCERG:IL3RB, PubMed

KI2L4, Complex: FCERG:KI2L4, PubMed

LAT, Complex: LCP2:LAT:LYN:FCERG:PLCG2:GRB2:KSYK, PubMed

NCTR1, Complex: FCERG:NCTR1, PubMed

Domains

AA: 21-51, PDBID: 2HAC, Subunit B, Seq Identity:51%, T-cell surface glycoprotein CD3 zeta chain

AA: 62-81, PDBID: 1TCE, Subunit B, Seq Identity:52%, Immunoreceptor tyrosine-based activation motif

UniProt annotation for FCERG_HUMAN » High affinity immunoglobulin epsilon receptor subunit gamma
FUNCTION: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.

SUBUNIT: IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with CLEC4E.

UniProt features for FCERG_HUMAN » High affinity immunoglobulin epsilon receptor subunit gamma
SIGNAL 1 18 Potential.
CHAIN 19 86 High affinity immunoglobulin epsilon receptor subunit gamma.
DOMAIN 54 82 ITAM.
DISULFID 25 25 Interchain (By similarity).
Amino Acid Sequence for FCERG_HUMAN » High affinity immunoglobulin epsilon receptor subunit gamma
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV RKAAITSYEK SDGVYTGLST RNQETYETLK HEKPPQ