FCERA_HUMAN » High affinity immunoglobulin epsilon receptor subunit alpha

FCERA_HUMAN » High affinity immunoglobulin epsilon receptor subunit alpha
Magnify FCERA_HUMAN » High affinity immunoglobulin epsilon receptor subunit alphaEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCERA_HUMAN » High affinity immunoglobulin epsilon receptor subunit alpha » Fc-epsilon RI-alpha;FcERI; IgE Fc receptor subunit alpha;
Hydrophobic Thickness 29.6 ± 1.8 Å
Tilt Angle 0 ± 1°
ΔGtransfer -35.0 kcal/mol
ΔGfold -15.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 202-225 (198-227)
Pathways

Asthma (KEGG)

Fc epsilon RI signaling pathway (KEGG)

PDB 1j87 (26-197), 1j88 (26-197), 1j89 (26-197), 1f2q (26-201), 1j86 (26-201), 1rpq (A/B/C/D=26-201), 1f6a (A=26-201), 2y7q (A=26-201)
OPM none
Complexes

FCERA:FCERA_HUMAN

Interactions

FCERA, Complex: Homodimer of IgE receptor, alpha chain, PDBID: 1RPQ

FCERG, Complex: FCERA:FCERG, PubMed

Domains

AA: 29-96, PDBID: 1F2Q, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 112-194, PDBID: 1F2Q, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for FCERA_HUMAN » High affinity immunoglobulin epsilon receptor subunit alpha
FUNCTION: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

SUBUNIT: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.

UniProt features for FCERA_HUMAN » High affinity immunoglobulin epsilon receptor subunit alpha
SIGNAL 1 25
CHAIN 26 257 High affinity immunoglobulin epsilon receptor subunit alpha.
DOMAIN 30 110 Ig-like 1.
DOMAIN 111 193 Ig-like 2.
DISULFID 51 93
DISULFID 132 176
Amino Acid Sequence for FCERA_HUMAN » High affinity immunoglobulin epsilon receptor subunit alpha
MAPAMESPTL LCVALLFFAP DGVLAVPQKP KVSLNPPWNR IFKGENVTLT CNGNNFFEVS STKWFHNGSL SEETNSSLNI VNAKFEDSGE YKCQHQQVNE SEPVYLEVFS DWLLLQASAE VVMEGQPLFL RCHGWRNWDV YKVIYYKDGE ALKYWYENHN ISITNATVED SGTYYCTGKV WQLDYESEPL NITVIKAPRE KYWLQFFIPL LVVILFAVDT GLFISTQQQV TFLLKIKRTR KGFRLLNPHP KPNPKNN