FCER2_HUMAN » Low affinity immunoglobulin epsilon Fc receptor

FCER2_HUMAN » Low affinity immunoglobulin epsilon Fc receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCER2_HUMAN » Low affinity immunoglobulin epsilon Fc receptor » BLAST-2;C-type lectin domain family 4 member J;Fc-epsilon-RII;Immunoglobulin E-binding factor;Lymphocyte IgE receptor;
Hydrophobic Thickness 34.4 ± 2.0 Å
Tilt Angle 6 ± 1°
ΔGtransfer -42.9 kcal/mol
ΔGfold -18.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 22-48 (22-50)
Pathways

Epstein-Barr virus infection (KEGG)

Hematopoietic cell lineage (KEGG)

PDB 2h2t (150-321), 1t8c (156-298), 4j6p (156-298), 4j6n (156-298), 4j6m (156-298), 4j6l (156-298), 4j6k (156-298), 4j6j (156-298), 4gk1 (156-298), 4gjx (156-298), 4gj0 (156-298), 4g9a (156-298), 4g96 (156-298), 1t8d (156-298), 4gi0 (A/B/C=156-298), 2h2r (A/B=150-321), 4j6q (A=156-298), 4ki1 (E/F/G/H=156-298), 4gko (G/H...=156-298), 4ezm (G/H...=156-298)
OPM none
Complexes

FCER2:FCER2_HUMAN

Interactions

CR2, Complex: FCER2:CR2, PubMed

FCER2, Complex: Homodimer of immunoglobulin epsilon FC receptor, PDBID: 2H2R

ITAV, Complex: ITB3:CD47:ITAV:FCER2, PubMed

ITB2, Complex: ITB2:FCER2, PubMed

Domains

AA: 180-284, PDBID: 1T8C, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for FCER2_HUMAN » Low affinity immunoglobulin epsilon Fc receptor
FUNCTION: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

SUBUNIT: Homotrimer.

MISCELLANEOUS: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

UniProt features for FCER2_HUMAN » Low affinity immunoglobulin epsilon Fc receptor
CHAIN 1 321 Low affinity immunoglobulin epsilon Fc receptor membrane-bound form.
CHAIN 150 321 Low affinity immunoglobulin epsilon Fc receptor soluble form.
REPEAT 69 89
REPEAT 90 110
REPEAT 111 131
DOMAIN 162 284 C-type lectin.
SITE 149 150 Cleavage.
DISULFID 160 288
DISULFID 163 174
DISULFID 191 282
DISULFID 259 273
Amino Acid Sequence for FCER2_HUMAN » Low affinity immunoglobulin epsilon Fc receptor
MEEGQYSEIE ELPRRRCCRR GTQIVLLGLV TAALWAGLLT LLLLWHWDTT QSLKQLEERA ARNVSQVSKN LESHHGDQMA QKSQSTQISQ ELEELRAEQQ RLKSQDLELS WNLNGLQADL SSFKSQELNE RNEASDLLER LREEVTKLRM ELQVSSGFVC NTCPEKWINF QRKCYYFGKG TKQWVHARYA CDDMEGQLVS IHSPEEQDFL TKHASHTGSW IGLRNLDLKG EFIWVDGSHV DYSNWAPGEP TSRSQGEDCV MMRGSGRWND AFCDRKLGAW VCDRLATCTP PASEGSAESM GPDSRPDPDG RLPTPSAPLH S