FCAR_HUMAN » Immunoglobulin alpha Fc receptor

FCAR_HUMAN » Immunoglobulin alpha Fc receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCAR_HUMAN » Immunoglobulin alpha Fc receptor » IgA Fc receptor;
Hydrophobic Thickness 34.4 ± 2.8 Å
Tilt Angle 13 ± 4°
ΔGtransfer -24.1 kcal/mol
ΔGfold -14.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 224-247 (221-247)
Pathways

Phagosome (KEGG)

Staphylococcus aureus infection (KEGG)

PDB 1uct (21-229), 1ovz (22-216), 1ow0 (C/D=22-216)
OPM none
Complexes none
Interactions

CD79A, Complex: FCAR:CD79A, PubMed

FCGR1, Complex: FCAR:FCGR1, PubMed

PILRA, Complex: FCAR:PILRA, PubMed

Domains

AA: 28-119, PDBID: 1ovz, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 125-215, PDBID: 1ovz, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for FCAR_HUMAN » Immunoglobulin alpha Fc receptor
FUNCTION: Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

SUBUNIT: Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.

TISSUE SPECIFICITY: Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.

UniProt features for FCAR_HUMAN » Immunoglobulin alpha Fc receptor
SIGNAL 1 21 Potential.
CHAIN 22 287 Immunoglobulin alpha Fc receptor.
DOMAIN 42 107 Ig-like C2-type 1.
DOMAIN 139 200 Ig-like C2-type 2.
DISULFID 49 100
DISULFID 146 193
Amino Acid Sequence for FCAR_HUMAN » Immunoglobulin alpha Fc receptor
MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA LLAILVENWH SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK