FCAMR_HUMAN » High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor

FCAMR_HUMAN » High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FCAMR_HUMAN » High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor » Fc alpha/mu receptor;
Hydrophobic Thickness 34.0 ± 2.0 Å
Tilt Angle 3 ± 8°
ΔGtransfer -26.0 kcal/mol
ΔGfold -17.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 451-474 (444-478)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 65-171, PDBID: 1XED, Subunit C, Seq Identity:45%, Immunoglobulin V-set domain

UniProt annotation for FCAMR_HUMAN » High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
FUNCTION: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.

TISSUE SPECIFICITY: Expressed by mesangial cells.

INDUCTION: Up-regulated by IFNG/IFN-gamma in mesangial cells.

UniProt features for FCAMR_HUMAN » High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
SIGNAL 1 16 Potential.
CHAIN 17 532 High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor.
DOMAIN 61 169 Ig-like V-type.
REGION 75 97 Mediates immunoglobulin Fc fragment- binding (By similarity).
DISULFID 82 153 By similarity.
Amino Acid Sequence for FCAMR_HUMAN » High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
MPLFLILCLL QGSSFALPQK RPHPRWLWEG SLPSRTHLRA MGTLRPSSPL CWREESSFAA PNSLKGSRLV SGEPGGAVTI QCHYAPSSVN RHQRKYWCRL GPPRWICQTI VSTNQYTHHR YRDRVALTDF PQRGLFVVRL SQLSPDDIGC YLCGIGSENN MLFLSMNLTI SAGPASTLPT ATPAAGELTM RSYGTASPVA NRWTPGTTQT LGQGTAWDTV ASTPGTSKTT ASAEGRRTPG ATRPAAPGTG SWAEGSVKAP APIPESPPSK SRSMSNTTEG VWEGTRSSVT NRARASKDRR EMTTTKADRP REDIEGVRIA LDAAKKVLGT IGPPALVSET LAWEILPQAT PVSKQQSQGS IGETTPAAGM WTLGTPAADV WILGTPAADV WTSMEAASGE GSAAGDLDAA TGDRGPQATL SQTPAVGPWG PPGKESSVKR TFPEDESSSR TLAPVSTMLA LFMLMALVLL QRKLWRRRTS QEAERVTLIQ MTHFLEVNPQ ADQLPHVERK MLQDDSLPAG ASLTAPERNP GP