FBCD1_HUMAN » Fibrinogen C domain-containing protein 1

FBCD1_HUMAN » Fibrinogen C domain-containing protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FBCD1_HUMAN » Fibrinogen C domain-containing protein 1 »
Hydrophobic Thickness 34.8 ± 4.8 Å
Tilt Angle 20 ± 5°
ΔGtransfer -26.6 kcal/mol
ΔGfold -22.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 30-54 (30-59)
Pathways none
PDB 4m7f (A/B=236-461), 4m7h (A/B=236-461)
OPM none
Complexes none
Interactions none
Domains

AA: 240-457, PDBID: 4M7F, Subunit A, Seq Identity:100%, Fibrinogen beta and gamma chains, C-terminal globular domain

UniProt annotation for FBCD1_HUMAN » Fibrinogen C domain-containing protein 1
FUNCTION: Acetyl group-binding receptor which shows a high- affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.

SUBUNIT: Homotetramer; disulfide-linked.

TISSUE SPECIFICITY: Expressed in the small and large intestinal epithelial cells with a highly polarized localization to the apical surface corresponding to the brush border and in the ducts of the salivary gland.

UniProt features for FBCD1_HUMAN » Fibrinogen C domain-containing protein 1
CHAIN 1 461 Fibrinogen C domain-containing protein 1.
DOMAIN 235 458 Fibrinogen C-terminal.
SITE 405 405 Implicated in ligand binding.
SITE 415 415 Implicated in ligand binding.
SITE 431 431 Implicated in ligand binding.
SITE 432 432 Implicated in ligand binding.
DISULFID 244 273 By similarity.
DISULFID 401 414 By similarity.
Amino Acid Sequence for FBCD1_HUMAN » Fibrinogen C domain-containing protein 1
MVNDRWKTMG GAAQLEDRPR DKPQRPSCGY VLCTVLLALA VLLAVAVTGA VLFLNHAHAP GTAPPPVVST GAASANSALV TVERADSSHL SILIDPRCPD LTDSFARLES AQASVLQALT EHQAQPRLVG DQEQELLDTL ADQLPRLLAR ASELQTECMG LRKGHGTLGQ GLSALQSEQG RLIQLLSESQ GHMAHLVNSV SDILDALQRD RGLGRPRNKA DLQRAPARGT RPRGCATGSR PRDCLDVLLS GQQDDGVYSV FPTHYPAGFQ VYCDMRTDGG GWTVFQRRED GSVNFFRGWD AYRDGFGRLT GEHWLGLKRI HALTTQAAYE LHVDLEDFEN GTAYARYGSF GVGLFSVDPE EDGYPLTVAD YSGTAGDSLL KHSGMRFTTK DRDSDHSENN CAAFYRGAWW YRNCHTSNLN GQYLRGAHAS YADGVEWSSW TGWQYSLKFS EMKIRPVRED R