FAT3_HUMAN » Protocadherin Fat 3

FAT3_HUMAN » Protocadherin Fat 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FAT3_HUMAN » Protocadherin Fat 3 » hFat3; Cadherin family member 15;FAT tumor suppressor homolog 3;
Hydrophobic Thickness 34.8 ± 0.8 Å
Tilt Angle 1 ± 6°
ΔGtransfer -31.2 kcal/mol
ΔGfold -28.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 4154-4176 (4152-4178)
Pathways none
PDB none
OPM none
Complexes none
Interactions

RYK, Complex: FAT3:RYK, PubMed

Domains

AA: 163-257, PDBID: 2EE0, Subunit A, Seq Identity:33%, Cadherin domain

AA: 477-569, PDBID: 3PPE, Subunit A, Seq Identity:36%, Cadherin domain

AA: 731-822, PDBID: 3UBH, Subunit A, Seq Identity:31%, Cadherin domain

AA: 836-927, PDBID: 2WCP, Subunit A, Seq Identity:39%, Cadherin domain

AA: 941-1032, PDBID: 2WCP, Subunit A, Seq Identity:43%, Cadherin domain

AA: 1048-1139, PDBID: 3PPE, Subunit A, Seq Identity:39%, Cadherin domain

AA: 1153-1245, PDBID: 2EE0, Subunit A, Seq Identity:36%, Cadherin domain

AA: 1259-1348, PDBID: 3UBH, Subunit A, Seq Identity:31%, Cadherin domain

AA: 1465-1557, PDBID: 4ZI8, Subunit B, Seq Identity:30%, Cadherin domain

AA: 1571-1662, PDBID: 1NCJ, Subunit A, Seq Identity:32%, Cadherin domain

AA: 1676-1760, PDBID: 3PPE, Subunit A, Seq Identity:33%, Cadherin domain

AA: 1774-1872, PDBID: 3UBH, Subunit A, Seq Identity:26%, Cadherin domain

AA: 1987-2075, PDBID: 2WCP, Subunit A, Seq Identity:28%, Cadherin domain

AA: 2089-2179, PDBID: 3UBH, Subunit A, Seq Identity:34%, Cadherin domain

AA: 2191-2278, PDBID: 4ZI9, Subunit B, Seq Identity:31%, Cadherin domain

AA: 2292-2385, PDBID: 3PPE, Subunit A, Seq Identity:34%, Cadherin domain

AA: 2399-2487, PDBID: 3PPE, Subunit A, Seq Identity:30%, Cadherin domain

AA: 2501-2591, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 2605-2699, PDBID: 4ZI8, Subunit B, Seq Identity:32%, Cadherin domain

AA: 2819-2915, PDBID: 2O72, Subunit A, Seq Identity:35%, Cadherin domain

AA: 2929-3020, PDBID: 4ZPS, Subunit A, Seq Identity:36%, Cadherin domain

AA: 3034-3121, PDBID: 4ZPS, Subunit A, Seq Identity:32%, Cadherin domain

AA: 3136-3227, PDBID: 2WCP, Subunit A, Seq Identity:36%, Cadherin domain

AA: 3241-3332, PDBID: 2O72, Subunit A, Seq Identity:37%, Cadherin domain

AA: 3346-3437, PDBID: 4ZPM, Subunit A, Seq Identity:35%, Cadherin domain

AA: 3451-3542, PDBID: 4ZI8, Subunit B, Seq Identity:32%, Cadherin domain

AA: 3865-3994, PDBID: 2JD4, Subunit A, Seq Identity:22%, Laminin G domain

UniProt annotation for FAT3_HUMAN » Protocadherin Fat 3
FUNCTION: May play a role in the interactions between neurites derived from specific subsets of neurons during development.

TISSUE SPECIFICITY: Expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate.

UniProt features for FAT3_HUMAN » Protocadherin Fat 3
SIGNAL 1 32 Potential.
CHAIN 33 4589 Protocadherin Fat 3.
DOMAIN 44 158 Cadherin 1.
DOMAIN 159 266 Cadherin 2.
DOMAIN 264 375 Cadherin 3.
DOMAIN 377 472 Cadherin 4.
DOMAIN 473 578 Cadherin 5.
DOMAIN 579 681 Cadherin 6.
DOMAIN 727 831 Cadherin 7.
DOMAIN 832 936 Cadherin 8.
DOMAIN 937 1043 Cadherin 9.
DOMAIN 1044 1148 Cadherin 10.
DOMAIN 1149 1254 Cadherin 11.
DOMAIN 1255 1359 Cadherin 12.
DOMAIN 1363 1460 Cadherin 13.
DOMAIN 1461 1566 Cadherin 14.
DOMAIN 1567 1769 Cadherin 15.
DOMAIN 1770 1883 Cadherin 16.
DOMAIN 1884 1986 Cadherin 17.
DOMAIN 1983 2084 Cadherin 18.
DOMAIN 2085 2186 Cadherin 19.
DOMAIN 2187 2287 Cadherin 20.
DOMAIN 2288 2394 Cadherin 21.
DOMAIN 2395 2496 Cadherin 22.
DOMAIN 2497 2600 Cadherin 23.
DOMAIN 2601 2708 Cadherin 24.
DOMAIN 2709 2814 Cadherin 25.
DOMAIN 2815 2924 Cadherin 26.
DOMAIN 2925 3029 Cadherin 27.
DOMAIN 3030 3131 Cadherin 28.
DOMAIN 3132 3236 Cadherin 29.
DOMAIN 3237 3341 Cadherin 30.
DOMAIN 3342 3446 Cadherin 31.
DOMAIN 3447 3551 Cadherin 32.
DOMAIN 3552 3653 Cadherin 33.
DOMAIN 3795 3833 EGF-like 1.
DOMAIN 3835 4018 Laminin G-like.
DOMAIN 4021 4058 EGF-like 2.
DOMAIN 4060 4096 EGF-like 3.
DOMAIN 4098 4134 EGF-like 4; calcium-binding (Potential).
DISULFID 3799 3810 By similarity.
DISULFID 3804 3822 By similarity.
DISULFID 3824 3832 By similarity.
DISULFID 3985 4018 By similarity.
DISULFID 4025 4036 By similarity.
DISULFID 4030 4046 By similarity.
DISULFID 4048 4057 By similarity.
DISULFID 4064 4075 By similarity.
DISULFID 4069 4084 By similarity.
DISULFID 4086 4095 By similarity.
DISULFID 4102 4113 By similarity.
DISULFID 4107 4122 By similarity.
DISULFID 4124 4133 By similarity.
Amino Acid Sequence for FAT3_HUMAN » Protocadherin Fat 3
MDIIMGHCVG TRPPACCLIL LLFKLLATVS QGLPGTGPLG FHFTHSIYNA TVYENSAART YVNSQSRMGI TLIDLSWDIK YRIVSGDEEG FFKAEEVIIA DFCFLRIRTK GGNSAILNRE IQDNYLLIVK GSVRGEDLEA WTKVNIQVLD MNDLRPLFSP TTYSVTIAES TPLRTSVAQV TATDADIGSN GEFYYYFKNK VDLFSVHPTS GVISLSGRLN YDEKNRYDLE ILAVDRGMKL YGNNGVSSTA KLYVHIERIN EHAPTIHVVT HVPFSLEKEP TYAVVTVDDL DDGANGEIES VSIVAGDPLD QFFLAKEGKW LNEYKIKERK QIDWESFPYG YNLTLQAKDK GSPQKCSALK AVYIGNPTRD TVPIRFEKEV YDVSISEFSP PGVVVAIVKL SPEPIDVEYK LSPGEDAVYF KINPRSGLIV TARPLNTVKK EVYKLEVTNK EGDLKAQVTI SIEDANDHTP EFQQPLYDAY VNESVPVGTS VLTVSASDKD KGENGYITYS IASLNLLPFV INQFTGVIST TEELDFESSP EIYRFIVRAS DWGSPYRHES EVNVTIRIGN VNDNSPLFEK VACQGVISYD FPVGGHITAV SAIDIDELEL VKYKIISGNE LGFFYLNPDS GVLQLKKSLT NSGIKNGNFA LRITATDGEN LADPMSINIS VLHGKVSSKS FSCRETRVAQ KLAEKLLIKA KANGKLNLED GFLDFYSINR QGPYFDKSFP SDVAVKEDLP VGANILKIKA YDADSGFNGK VLFTISDGNT DSCFNIDMET GQLKVLMPMD REHTDLYLLN ITIYDLGNPQ KSSWRLLTIN VEDANDNSPV FIQDSYSVNI LESSGIGTEI IQVEARDKDL GSNGEVTYSV LTDTQQFAIN SSTGIVYVAD QLDRESKANY SLKIEARDKA ESGQQLFSVV TLKVFLDDVN DCSPAFIPSS YSVKVLEDLP VGTVIAWLET HDPDLGLGGQ VRYSLVNDYN GRFEIDKASG AIRLSKELDY EKQQFYNLTV RAKDKGRPVS LSSVSFVEVE VVDVNENLHT PYFPDFAVVG SVKENSRIGT SVLQVTARDE DSGRDGEIQY SIRDGSGLGR FSIDDESGVI TAADILDRET MGSYWLTVYA TDRGVVPLYS TIEVYIEVED VNDNAPLTSE PIYYPVVMEN SPKDVSVIQI QAEDPDSSSN EKLTYRITSG NPQNFFAINI KTGLITTTSR KLDREQQAEH FLEVTVTDGG PSPKQSTIWV VVQVLDENDN KPQFPEKVYQ IKLPERDRKK RGEPIYRAFA FDRDEGPNAE ISYSIVDGND DGKFFIDPKT GMVSSRKQFT AGSYDILTIK AVDNGRPQKS STARLHIEWI KKPPPSPIPL TFDEPFYNFT VMESDRVTEI VGVVSVQPAN TPLWFDIVGG NFDSAFDAEK GVGTIVIAKP LDAEQRSIYN MSVEVTDGTN VAVTQVFIKV LDNNDNGPEF SQPNYDVTIS EDVLPDTEIL QIEATDRDEK HKLSYTVHSS IDSISMRKFR IDPSTGVLYT AERLDHEAQD KHILNIMVRD QEFPYRRNLA RVIVNVEDAN DHSPYFTNPL YEASVFESAA LGSAVLQVTA LDKDKGENAE LIYTIEAGNT GNMFKIEPVL GIITICKEPD MTTMGQFVLS IKVTDQGSPP MSATAIVRIS VTMSDNSHPK FIHKDYQAEV NENVDIGTSV ILISAISQST LIYEVKDGDI NGIFTINPYS GVITTQKALD YERTSSYQLI IQATNMAGMA SNATVNIQIV DENDNAPVFL FSQYSGSLSE AAPINSIVRS LDNSPLVIRA TDADSNRNAL LVYQIVESTA KKFFTVDSST GAIRTIANLD HETIAHFHFH VHVRDSGSPQ LTAESPVEVN IEVTDVNDNP PVFTQAVFET ILLLPTYVGV EVLKVSATDP DSEVPPELTY SLMEGSLDHF LIDSNSGVLT IKNNNLSKDH YMLIVKVSDG KFYSTSMVTI MVKEAMDSGL HFTQSFYSTS ISENNTNITK VAIVNAVGNR LNEPLKYSIL NPGNKFKIKS TSGVIQTTGV PFDREEQELY ELVVEASREL DHLRVARVVV RVNIEDINDN SPVFVGLPYY AAVQVDAEPG TLIYQVTAID KDKGPNGEVT YVLQDDYGHF EINPNSGNVI LKEAFNSDLS NIEYGVTILA KDGGKPSLST SVELPITIVN KAMPVFDKPF YTASVNEDIR MNTPILSINA TSPEGQGIIY IIIDGDPFKQ FNIDFDTGVL KVVSPLDYEV TSAYKLTIRA SDALTGARAE VTVDLLVNDV NDNPPIFDQP TYNTTLSEAS LIGTPVLQVV SIDADSENNK MVHYQIVQDT YNSTDYFHID SSSGLILTAR MLDHELVQHC TLKVRSIDSG FPSLSSEVLV HIYISDVNDN PPVFNQLIYE SYVSELAPRG HFVTCVQASD ADSSDFDRLE YSILSGNDRT SFLMDSKSGV ITLSNHRKQR MEPLYSLNVS VSDGLFTSTA QVHIRVLGAN LYSPAFSQST YVAEVRENVA AGTKVIHVRA TDGDPGTYGQ ISYAIINDFA KDRFLIDSNG QVITTERLDR ENPLEGDVSI FVRALDGGGR TTFCTVRVIV VDENDNAPQF MTVEYRASVR ADVGRGHLVT QVQAIDPDDG ANSRITYSLY SEASVSVADL LEIDPDNGWM VTKGNFNQLK NTVLSFFVKA VDGGIPVKHS LIPVYIHVLP PETFLPSFTQ SQYSFTIAED TAIGSTVDTL RILPSQNVWF STVNGERPEN NKGGIFVIEQ ETGTIKLDKR LDRETSPAFH FKVAATIPLD KVDIVFTVDV DIKVLDLNDN KPVFETSSYD TIIMEGMPVG TKLTQVRAID MDWGANGQVT YSLHSDSQPE KVMEAFNIDS NTGWISTLKD LDHETDPTFT FSVVASDLGE AFSLSSTALV SVRVTDINDN APVFAQEVYR GNVKESDPPG EVVAVLSTWD RDTSDVNRQV SYHITGGNPR GRFALGLVQS EWKVYVKRPL DREEQDIYFL NITATDGLFV TQAMVEVSVS DVNDNSPVCD QVAYTALLPE DIPSNKIILK VSAKDADIGS NGYIRYSLYG SGNSEFFLDP ESGELKTLAL LDRERIPVYS LMAKATDGGG RFCQSNIHLI LEDVNDNPPV FSSDHYNTCV YENTATKALL TRVQAVDPDI GINRKVVYSL ADSAGGVFSI DSSSGIIILE QPLDREQQSS YNISVRATDQ SPGQSLSSLT TVTITVLDIN DNPPVFERRD YLVTVPEDTS PGTQVLAVFA TSKDIGTNAE ITYLIRSGNE QGKFKINPKT GGISVSEVLD YELCKRFYLV VEAKDGGTPA LSAVATVNIN LTDVNDNPPK FSQDVYSAVI SEDALVGDSV ILLIAEDVDS QPNGQIHFSI VNGDRDNEFT VDPVLGLVKV KKKLDRERVS GYSLLVQAVD SGIPAMSSTA TVNIDISDVN DNSPVFTPAN YTAVIQENKP VGTSILQLVV TDRDSFHNGP PFSFSILSGN EEEEFVLDPH GILRSAVVFQ HTESLEYVLC VQAKDSGKPQ QVSHTYIRVR VIEESTHKPT AIPLEIFIVT MEDDFPGGVI GKIHATDQDM YDVLTFALKS EQKSLFKVNS HDGKIIALGG LDSGKYVLNV SVSDGRFQVP IDVVVHVEQL VHEMLQNTVT IRFENVSPED FVGLHMHGFR RTLRNAVLTQ KQDSLRIISI QPVAGTNQLD MLFAVEMHSS EFYKPAYLIQ KLSNARRHLE NIMRISAILE KNCSGLDCQE QHCEQGLSLD SHALMTYSTA RISFVCPRFY RNVRCTCNGG LCPGSNDPCV EKPCPGDMQC VSYEASRRPF LCQCPPGKLG ECSGHTSLSF AGNSYIKYRL SENSKEEDFK LALRLRTLQS NGIIMYTRAN PCIILKIVDG KLWFQLDCGS GPGILGISGR AVNDGSWHSV FLELNRNFTS LSLDDSYVER RRAPLYFQTL STESSIYFGA LVQADNIRSL TDTRVTQVLS GFQGCLDSVI LNNNELPLQN KRSSFAEVVG LTELKLGCVL YPDACKRSPC QHGGSCTGLP SGGYQCTCLS QFTGRNCESE ITACFPNPCR NGGSCDPIGN TFICNCKAGL TGVTCEEDIN ECEREECENG GSCVNVFGSF LCNCTPGYVG QYCGLRPVVV PNIQAGHSYV GKEELIGIAV VLFVIFILVV LFIVFRKKVF RKNYSRNNIT LVQDPATAAL LNKSNGIPFR NLRGSGDGRN VYQEVGPPQV PVRPMAYTPC FQSDSRSNLD KIVDGLGGEH QEMTTFHPES PRILTARRGV VVCSVAPNLP AVSPCRSDCD SIRKNGWDAG TENKGVDDPG EVTCFAGSNK GSNSEVQSLS SFQSDSGDDN ASIVTVIQLV NNVVDTIENE VSVMDQGQNY NRAYHWDTSD WMPGARLSDI EEVPNYENQD GGSAHQGSTR ELESDYYLGG YDIDSEYPPP HEEEFLSQDQ LPPPLPEDFP DQYEALPPSQ PVSLASTLSP DCRRRPQFHP SQYLPPHPFP NETDLVGPPA SCEFSTFAVS MNQGTEPTGP ADSVSLSLHN SRGTSSSDVS ANCGFDDSEV AMSDYESVGE LSLASLHIPF VETQHQTQV