FAT2_HUMAN » Protocadherin Fat 2

FAT2_HUMAN » Protocadherin Fat 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FAT2_HUMAN » Protocadherin Fat 2 » hFat2; Cadherin family member 8;Multiple epidermal growth factor-like domains protein 1;Multiple EGF-like domains protein 1;
Hydrophobic Thickness 32.8 ± 2.2 Å
Tilt Angle 1 ± 1°
ΔGtransfer -40.1 kcal/mol
ΔGfold -20.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 4048-4070 (4046-4073)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 153-247, PDBID: 2WCP, Subunit A, Seq Identity:29%, Cadherin domain

AA: 463-553, PDBID: 4ZPS, Subunit A, Seq Identity:36%, Cadherin domain

AA: 569-659, PDBID: 1EDH, Subunit B, Seq Identity:28%, Cadherin domain

AA: 720-811, PDBID: 4ZPN, Subunit B, Seq Identity:34%, Cadherin domain

AA: 825-916, PDBID: 2WCP, Subunit A, Seq Identity:35%, Cadherin domain

AA: 930-1019, PDBID: 4ZI9, Subunit B, Seq Identity:34%, Cadherin domain

AA: 1037-1128, PDBID: 4ZPM, Subunit A, Seq Identity:36%, Cadherin domain

AA: 1142-1233, PDBID: 2WBX, Subunit A, Seq Identity:33%, Cadherin domain

AA: 1247-1335, PDBID: 2WCP, Subunit A, Seq Identity:32%, Cadherin domain

AA: 1354-1438, PDBID: 2WBX, Subunit A, Seq Identity:25%, Cadherin domain

AA: 1453-1546, PDBID: 4ZI8, Subunit B, Seq Identity:28%, Cadherin domain

AA: 1560-1651, PDBID: 3UBH, Subunit A, Seq Identity:35%, Cadherin domain

AA: 1665-1749, PDBID: 4ZI9, Subunit B, Seq Identity:30%, Cadherin domain

AA: 1774-1863, PDBID: 2V37, Subunit A, Seq Identity:23%, Cadherin domain

AA: 1973-2061, PDBID: 4ZPL, Subunit A, Seq Identity:24%, Cadherin domain

AA: 2075-2164, PDBID: 4ZPN, Subunit B, Seq Identity:36%, Cadherin domain

AA: 2176-2263, PDBID: 4ZI9, Subunit B, Seq Identity:34%, Cadherin domain

AA: 2277-2370, PDBID: 4ZPM, Subunit A, Seq Identity:35%, Cadherin domain

AA: 2384-2472, PDBID: 4ZPS, Subunit A, Seq Identity:30%, Cadherin domain

AA: 2486-2576, PDBID: 2EE0, Subunit A, Seq Identity:35%, Cadherin domain

AA: 2590-2682, PDBID: 4ZPL, Subunit A, Seq Identity:34%, Cadherin domain

AA: 2696-2788, PDBID: 2A62, Subunit A, Seq Identity:26%, Cadherin domain

AA: 2802-2897, PDBID: 2WCP, Subunit A, Seq Identity:38%, Cadherin domain

AA: 2911-3002, PDBID: 4ZPL, Subunit A, Seq Identity:31%, Cadherin domain

AA: 3016-3104, PDBID: 4ZI9, Subunit B, Seq Identity:39%, Cadherin domain

AA: 3119-3209, PDBID: 2WCP, Subunit A, Seq Identity:33%, Cadherin domain

AA: 3223-3312, PDBID: 4ZI8, Subunit B, Seq Identity:29%, Cadherin domain

AA: 3326-3417, PDBID: 4ZPL, Subunit A, Seq Identity:35%, Cadherin domain

AA: 3431-3522, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 3800-3921, PDBID: 2H0B, Subunit B, Seq Identity:22%, Laminin G domain

AA: 3951-3982, PDBID: 1EDM, Subunit B, Seq Identity:50%, EGF-like domain

AA: 3990-4020, PDBID: 4XBM, Subunit B, Seq Identity:41%, EGF-like domain

UniProt annotation for FAT2_HUMAN » Protocadherin Fat 2
FUNCTION: Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development (By similarity).

SUBUNIT: Homodimer.

TISSUE SPECIFICITY: Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level).

UniProt features for FAT2_HUMAN » Protocadherin Fat 2
SIGNAL 1 18 Potential.
CHAIN 19 4349 Protocadherin Fat 2.
DOMAIN 34 148 Cadherin 1.
DOMAIN 149 256 Cadherin 2.
DOMAIN 363 458 Cadherin 3.
DOMAIN 459 564 Cadherin 4.
DOMAIN 565 669 Cadherin 5.
DOMAIN 716 820 Cadherin 6.
DOMAIN 821 925 Cadherin 7.
DOMAIN 926 1032 Cadherin 8.
DOMAIN 1033 1137 Cadherin 9.
DOMAIN 1138 1242 Cadherin 10.
DOMAIN 1243 1346 Cadherin 11.
DOMAIN 1350 1448 Cadherin 12.
DOMAIN 1449 1555 Cadherin 13.
DOMAIN 1556 1660 Cadherin 14.
DOMAIN 1661 1758 Cadherin 15.
DOMAIN 1759 1872 Cadherin 16.
DOMAIN 1969 2070 Cadherin 17.
DOMAIN 2071 2171 Cadherin 18.
DOMAIN 2172 2272 Cadherin 19.
DOMAIN 2273 2379 Cadherin 20.
DOMAIN 2380 2481 Cadherin 21.
DOMAIN 2482 2585 Cadherin 22.
DOMAIN 2586 2691 Cadherin 23.
DOMAIN 2692 2797 Cadherin 24.
DOMAIN 2798 2906 Cadherin 25.
DOMAIN 2907 3011 Cadherin 26.
DOMAIN 3012 3113 Cadherin 27.
DOMAIN 3114 3218 Cadherin 28.
DOMAIN 3219 3321 Cadherin 29.
DOMAIN 3322 3426 Cadherin 30.
DOMAIN 3427 3531 Cadherin 31.
DOMAIN 3532 3642 Cadherin 32.
DOMAIN 3773 3944 Laminin G-like.
DOMAIN 3947 3984 EGF-like 1.
DOMAIN 3986 4022 EGF-like 2.
DISULFID 3912 3944 By similarity.
DISULFID 3951 3962 By similarity.
DISULFID 3956 3972 By similarity.
DISULFID 3974 3983 By similarity.
DISULFID 3990 4001 By similarity.
DISULFID 3995 4010 By similarity.
DISULFID 4012 4021 By similarity.
Amino Acid Sequence for FAT2_HUMAN » Protocadherin Fat 2
MTIALLGFAI FLLHCATCEK PLEGILSSSA WHFTHSHYNA TIYENSSPKT YVESFEKMGI YLAEPQWAVR YRIISGDVAN VFKTEEYVVG NFCFLRIRTK SSNTALLNRE VRDSYTLIIQ ATEKTLELEA LTRVVVHILD QNDLKPLFSP PSYRVTISED MPLKSPICKV TATDADLGQN AEFYYAFNTR SEMFAIHPTS GVVTVAGKLN VTWRGKHELQ VLAVDRMRKI SEGNGFGSLA ALVVHVEPAL RKPPAIASVV VTPPDSNDGT TYATVLVDAN SSGAEVESVE VVGGDPGKHF KAIKSYARSN EFSLVSVKDI NWMEYLHGFN LSLQARSGSG PYFYSQIRGF HLPPSKLSSL KFEKAVYRVQ LSEFSPPGSR VVMVRVTPAF PNLQYVLKPS SENVGFKLNA RTGLITTTKL MDFHDRAHYQ LHIRTSPGQA STVVVIDIVD CNNHAPLFNR SSYDGTLDEN IPPGTSVLAV TATDRDHGEN GYVTYSIAGP KALPFSIDPY LGIISTSKPM DYELMKRIYT FRVRASDWGS PFRREKEVSI FLQLRNLNDN QPMFEEVNCT GSIRQDWPVG KSIMTMSAID VDELQNLKYE IVSGNELEYF DLNHFSGVIS LKRPFINLTA GQPTSYSLKI TASDGKNYAS PTTLNITVVK DPHFEVPVTC DKTGVLTQFT KTILHFIGLQ NQESSDEEFT SLSTYQINHY TPQFEDHFPQ SIDVLESVPI NTPLARLAAT DPDAGFNGKL VYVIADGNEE GCFDIELETG LLTVAAPLDY EATNFYILNV TVYDLGTPQK SSWKLLTVNV KDWNDNAPRF PPGGYQLTIS EDTEVGTTIA ELTTKDADSE DNGRVRYTLL SPTEKFSLHP LTGELVVTGH LDRESEPRYI LKVEARDQPS KGHQLFSVTD LIITLEDVND NSPQCITEHN RLKVPEDLPP GTVLTFLDAS DPDLGPAGEV RYVLMDGAHG TFRVDLMTGA LILERELDFE RRAGYNLSLW ASDGGRPLAR RTLCHVEVIV LDVNENLHPP HFASFVHQGQ VQENSPSGTQ VIVVAAQDDD SGLDGELQYF LRAGTGLAAF SINQDTGMIQ TLAPLDREFA SYYWLTVLAV DRGSVPLSSV TEVYIEVTDA NDNPPQMSQA VFYPSIQEDA PVGTSVLQLD AWDPDSSSKG KLTFNITSGN YMGFFMIHPV TGLLSTAQQL DRENKDEHIL EVTVLDNGEP SLKSTSRVVV GILDVNDNPP IFSHKLFNVR LPERLSPVSP GPVYRLVASD LDEGLNGRVT YSIEDSYEEA FSIDLVTGVV SSNSTFTAGE YNILTIKATD SGQPPLSASV RLHIEWIPWP RPSSIPLAFD ETYYSFTVME TDPVNHMVGV ISVEGRPGLF WFNISGGDKD MDFDIEKTTG SIVIARPLDT RRRSNYNLTV EVTDGSRTIA TQVHIFMIAN INHHRPQFLE TRYEVRVPQD TVPGVELLRV QAIDQDKGKS LIYTIHGSQD PGSASLFQLD PSSGVLVTVG KLDLGSGPSQ HTLTVMVRDQ EIPIKRNFVW VTIHVEDGNL HPPRFTQLHY EASVPDTIAP GTELLQVRAM DADRGVNAEV HYSLLKGNSE GFFNINALLG IITLAQKLDQ ANHAPHTLTV KAEDQGSPQW HDLATVIIHV YPSDRSAPIF SKSEYFVEIP ESIPVGSPIL LVSAMSPSEV TYELREGNKD GVFSMNSYSG LISTQKKLDH EKISSYQLKI RGSNMAGAFT DVMVVVDIID ENDNAPMFLK STFVGQISEA APLYSMIMDK NNNPFVIHAS DSDKEANSLL VYKILEPEAL KFFKIDPSMG TLTIVSEMDY ESMPSFQFCV YVHDQGSPVL FAPRPAQVII HVRDVNDSPP RFSEQIYEVA IVGPIHPGME LLMVRASDED SEVNYSIKTG NADEAVTIHP VTGSISVLNP AFLGLSRKLT IRASDGLYQD TALVKISLTQ VLDKSLQFDQ DVYWAAVKEN LQDRKALVIL GAQGNHLNDT LSYFLLNGTD MFHMVQSAGV LQTRGVAFDR EQQDTHELAV EVRDNRTPQR VAQGLVRVSI EDVNDNPPKF KHLPYYTIIQ DGTEPGDVLF QVSATDEDLG TNGAVTYEFA EDYTYFRIDP YLGDISLKKP FDYQALNKYH LKVIARDGGT PSLQSEEEVL VTVRNKSNPL FQSPYYKVRV PENITLYTPI LHTQARSPEG LRLIYNIVEE EPLMLFTTDF KTGVLTVTGP LDYESKTKHV FTVRATDTAL GSFSEATVEV LVEDVNDNPP TFSQLVYTTS ISEGLPAQTP VIQLLASDQD SGRNRDVSYQ IVEDGSDVSK FFQINGSTGE MSTVQELDYE AQQHFHVKVR AMDKGDPPLT GETLVVVNVS DINDNPPEFR QPQYEANVSE LATCGHLVLK VQAIDPDSRD TSRLEYLILS GNQDRHFFIN SSSGIISMFN LCKKHLDSSY NLRVGASDGV FRATVPVYIN TTNANKYSPE FQQHLYEAEL AENAMVGTKV IDLLAIDKDS GPYGTIDYTI INKLASEKFS INPNGQIATL QKLDRENSTE RVIAIKVMAR DGGGRVAFCT VKIILTDEND NPPQFKASEY TVSIQSNVSK DSPVIQVLAY DADEGQNADV TYSVNPEDLV KDVIEINPVT GVVKVKDSLV GLENQTLDFF IKAQDGGPPH WNSLVPVRLQ VVPKKVSLPK FSEPLYTFSA PEDLPEGSEI GIVKAVAAQD PVIYSLVRGT TPESNKDGVF SLDPDTGVIK VRKPMDHEST KLYQIDVMAH CLQNTDVVSL VSVNIQVGDV NDNRPVFEAD PYKAVLTENM PVGTSVIQVT AIDKDTGRDG QVSYRLSADP GSNVHELFAI DSESGWITTL QELDCETCQT YHFHVVAYDH GQTIQLSSQA LVQVSITDEN DNAPRFASEE YRGSVVENSE PGELVATLKT LDADISEQNR QVTCYITEGD PLGQFGISQV GDEWRISSRK TLDREHTAKY LLRVTASDGK FQASVTVEIF VLDVNDNSPQ CSQLLYTGKV HEDVFPGHFI LKVSATDLDT DTNAQITYSL HGPGAHEFKL DPHTGELTTL TALDRERKDV FNLVAKATDG GGRSCQADIT LHVEDVNDNA PRFFPSHCAV AVFDNTTVKT PVAVVFARDP DQGANAQVVY SLPDSAEGHF SIDATTGVIR LEKPLQVRPQ APLELTVRAS DLGTPIPLST LGTVTVSVVG LEDYLPVFLN TEHSVQVPED APPGTEVLQL ATLTRPGAEK TGYRVVSGNE QGRFRLDART GILYVNASLD FETSPKYFLS IECSRKSSSS LSDVTTVMVN ITDVNEHRPQ FPQDPYSTRV LENALVGDVI LTVSATDEDG PLNSDITYSL IGGNQLGHFT IHPKKGELQV AKALDREQAS SYSLKLRATD SGQPPLHEDT DIAIQVADVN DNPPRFFQLN YSTTVQENSP IGSKVLQLIL SDPDSPENGP PYSFRITKGN NGSAFRVTPD GWLVTAEGLS RRAQEWYQLQ IQASDSGIPP LSSLTSVRVH VTEQSHYAPS ALPLEIFITV GEDEFQGGMV GKIHATDRDP QDTLTYSLAE EETLGRHFSV GAPDGKIIAA QGLPRGHYSF NVTVSDGTFT TTAGVHVYVW HVGQEALQQA MWMGFYQLTP EELVSDHWRN LQRFLSHKLD IKRANIHLAS LQPAEAVAGV DVLLVFEGHS GTFYEFQELA SIITHSAKEM EHSVGVQMRS AMPMVPCQGP TCQGQICHNT VHLDPKVGPT YSTARLSILT PRHHLQRSCS CNGTATRFSG QSYVRYRAPA ARNWHIHFYL KTLQPQAILL FTNETASVSL KLASGVPQLE YHCLGGFYGN LSSQRHVNDH EWHSILVEEM DASIRLMVDS MGNTSLVVPE NCRGLRPERH LLLGGLILLH SSSNVSQGFE GCLDAVVVNE EALDLLAPGK TVAGLLETQA LTQCCLHSDY CSQNTCLNGG KCSWTHGAGY VCKCPPQFSG KHCEQGRENC TFAPCLEGGT CILSPKGASC NCPHPYTGDR CEMEARGCSE GHCLVTPEIQ RGDWGQQELL IITVAVAFII ISTVGLLFYC RRCKSHKPVA MEDPDLLARS VGVDTQAMPA IELNPLSASS CNNLNQPEPS KASVPNELVT FGPNSKQRPV VCSVPPRLPP AAVPSHSDNE PVIKRTWSSE EMVYPGGAMV WPPTYSRNER WEYPHSEVTQ GPLPPSAHRH STPVVMPEPN GLYGGFPFPL EMENKRAPLP PRYSNQNLED LMPSRPPSPR ERLVAPCLNE YTAISYYHSQ FRQGGGGPCL ADGGYKGVGM RLSRAGPSYA VCEVEGAPLA GQGQPRVPPN YEGSDMVESD YGSCEEVMF