FAT1_HUMAN » Protocadherin Fat 1

FAT1_HUMAN » Protocadherin Fat 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FAT1_HUMAN » Protocadherin Fat 1 » Cadherin family member 7;Cadherin-related tumor suppressor homolog;Protein fat homolog;
Hydrophobic Thickness 34.0 ± 3.8 Å
Tilt Angle 31 ± 4°
ΔGtransfer -30.3 kcal/mol
ΔGfold -22.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 4181-4208 (4181-4212)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 154-248, PDBID: 2WCP, Subunit A, Seq Identity:37%, Cadherin domain

AA: 468-560, PDBID: 4ZI9, Subunit B, Seq Identity:35%, Cadherin domain

AA: 722-813, PDBID: 4ZI8, Subunit B, Seq Identity:33%, Cadherin domain

AA: 827-918, PDBID: 2A4E, Subunit A, Seq Identity:35%, Cadherin domain

AA: 932-1023, PDBID: 2WCP, Subunit A, Seq Identity:40%, Cadherin domain

AA: 1039-1130, PDBID: 1EDH, Subunit B, Seq Identity:35%, Cadherin domain

AA: 1144-1236, PDBID: 4NQQ, Subunit D, Seq Identity:34%, Cadherin domain

AA: 1261-1344, PDBID: 4ZPL, Subunit A, Seq Identity:28%, Cadherin domain

AA: 1363-1447, PDBID: 2WBX, Subunit A, Seq Identity:29%, Cadherin domain

AA: 1461-1553, PDBID: 2YST, Subunit A, Seq Identity:37%, Cadherin domain

AA: 1567-1658, PDBID: 3LND, Subunit B, Seq Identity:37%, Cadherin domain

AA: 1672-1756, PDBID: 3LND, Subunit B, Seq Identity:32%, Cadherin domain

AA: 1774-1868, PDBID: 2EE0, Subunit A, Seq Identity:27%, Cadherin domain

AA: 1891-1970, PDBID: 4ZPN, Subunit B, Seq Identity:28%, Cadherin domain

AA: 1984-2072, PDBID: 4ZPL, Subunit A, Seq Identity:28%, Cadherin domain

AA: 2086-2175, PDBID: 3UBH, Subunit A, Seq Identity:36%, Cadherin domain

AA: 2187-2274, PDBID: 4ZPS, Subunit A, Seq Identity:29%, Cadherin domain

AA: 2288-2381, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 2395-2483, PDBID: 2A62, Subunit A, Seq Identity:31%, Cadherin domain

AA: 2497-2587, PDBID: 2EE0, Subunit A, Seq Identity:32%, Cadherin domain

AA: 2601-2694, PDBID: 2EE0, Subunit A, Seq Identity:35%, Cadherin domain

AA: 2708-2800, PDBID: 4ZI8, Subunit B, Seq Identity:28%, Cadherin domain

AA: 2814-2909, PDBID: 2EE0, Subunit A, Seq Identity:34%, Cadherin domain

AA: 2923-3014, PDBID: 4ZI9, Subunit B, Seq Identity:35%, Cadherin domain

AA: 3028-3116, PDBID: 2EE0, Subunit A, Seq Identity:35%, Cadherin domain

AA: 3130-3221, PDBID: 2A62, Subunit A, Seq Identity:36%, Cadherin domain

AA: 3235-3326, PDBID: 3UBH, Subunit A, Seq Identity:36%, Cadherin domain

AA: 3340-3431, PDBID: 4ZPM, Subunit A, Seq Identity:35%, Cadherin domain

AA: 3445-3536, PDBID: 3PPE, Subunit A, Seq Identity:28%, Cadherin domain

AA: 3859-3985, PDBID: 3ASI, Subunit A, Seq Identity:23%, Laminin G domain

AA: 4017-4048, PDBID: 4XBM, Subunit B, Seq Identity:55%, EGF-like domain

AA: 4093-4123, PDBID: 1TPG, Subunit A, Seq Identity:51%, EGF-like domain

UniProt annotation for FAT1_HUMAN » Protocadherin Fat 1
FUNCTION: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.

SUBUNIT: Interacts (via the C-terminus 4300-4400 AA) with ATN1. Interacts with RERE. Interacts (via EVH1 domains) with ENAH (By similarity). Interacts (via cytoplasmic domain) with CTNNB1 (By similarity).

TISSUE SPECIFICITY: Expressed in many epithelial and some endothelial and smooth muscle cells.

DOMAIN: A PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation (By similarity).

UniProt features for FAT1_HUMAN » Protocadherin Fat 1
SIGNAL 1 21 Potential.
CHAIN 22 4588 Protocadherin Fat 1.
CHAIN ? 4588 Protocadherin Fat 1, nuclear form.
DOMAIN 35 149 Cadherin 1.
DOMAIN 150 257 Cadherin 2.
DOMAIN 368 463 Cadherin 3.
DOMAIN 464 569 Cadherin 4.
DOMAIN 570 673 Cadherin 5.
DOMAIN 718 822 Cadherin 6.
DOMAIN 823 927 Cadherin 7.
DOMAIN 928 1034 Cadherin 8.
DOMAIN 1035 1139 Cadherin 9.
DOMAIN 1140 1245 Cadherin 10.
DOMAIN 1246 1357 Cadherin 11.
DOMAIN 1359 1456 Cadherin 12.
DOMAIN 1457 1562 Cadherin 13.
DOMAIN 1563 1667 Cadherin 14.
DOMAIN 1668 1765 Cadherin 15.
DOMAIN 1766 1879 Cadherin 16.
DOMAIN 1880 1979 Cadherin 17.
DOMAIN 1980 2081 Cadherin 18.
DOMAIN 2082 2182 Cadherin 19.
DOMAIN 2183 2283 Cadherin 20.
DOMAIN 2284 2390 Cadherin 21.
DOMAIN 2391 2492 Cadherin 22.
DOMAIN 2493 2596 Cadherin 23.
DOMAIN 2597 2703 Cadherin 24.
DOMAIN 2704 2809 Cadherin 25.
DOMAIN 2810 2918 Cadherin 26.
DOMAIN 2919 3023 Cadherin 27.
DOMAIN 3024 3125 Cadherin 28.
DOMAIN 3126 3230 Cadherin 29.
DOMAIN 3231 3335 Cadherin 30.
DOMAIN 3336 3440 Cadherin 31.
DOMAIN 3441 3545 Cadherin 32.
DOMAIN 3546 3647 Cadherin 33.
DOMAIN 3790 3827 EGF-like 1.
DOMAIN 3829 4009 Laminin G-like.
DOMAIN 4013 4050 EGF-like 2.
DOMAIN 4052 4088 EGF-like 3.
DOMAIN 4089 4125 EGF-like 4.
DOMAIN 4127 4163 EGF-like 5; calcium-binding (Potential).
MOTIF 4204 4214 Nuclear localization signal (Potential).
MOTIF 4378 4382 PTB-like motif (By similarity).
DISULFID 3794 3805 By similarity.
DISULFID 3799 3816 By similarity.
DISULFID 3818 3826 By similarity.
DISULFID 3976 4009 By similarity.
DISULFID 4017 4028 By similarity.
DISULFID 4022 4038 By similarity.
DISULFID 4040 4049 By similarity.
DISULFID 4056 4067 By similarity.
DISULFID 4061 4076 By similarity.
DISULFID 4078 4087 By similarity.
DISULFID 4093 4104 By similarity.
DISULFID 4098 4113 By similarity.
DISULFID 4115 4124 By similarity.
DISULFID 4131 4142 By similarity.
DISULFID 4136 4151 By similarity.
DISULFID 4153 4162 By similarity.
Amino Acid Sequence for FAT1_HUMAN » Protocadherin Fat 1
MGRHLALLLL LLLLFQHFGD SDGSQRLEQT PLQFTHLEYN VTVQENSAAK TYVGHPVKMG VYITHPAWEV RYKIVSGDSE NLFKAEEYIL GDFCFLRIRT KGGNTAILNR EVKDHYTLIV KALEKNTNVE ARTKVRVQVL DTNDLRPLFS PTSYSVSLPE NTAIRTSIAR VSATDADIGT NGEFYYSFKD RTDMFAIHPT SGVIVLTGRL DYLETKLYEM EILAADRGMK LYGSSGISSM AKLTVHIEQA NECAPVITAV TLSPSELDRD PAYAIVTVDD CDQGANGDIA SLSIVAGDLL QQFRTVRSFP GSKEYKVKAI GDIDWDSHPF GYNLTLQAKD KGTPPQFSSV KVIHVTSPQF KAGPVKFEKD VYRAEISEFA PPNTPVVMVK AIPAYSHLRY VFKRTPGKAK FSLNYNTGLI SILEPVKRQQ AAHFELEVTT SDRKASTKVL VKVLGANSNP PEFTQTAYKA AFDENVPIGT TIMSLSAVDP DEGENGYVTY SIANLNHVPF AIDHFTGAVS TSENLDYELM PRVYTLRIRA SDWGLPYRRE VEVLATITLN NLNDNTPLFE KINCEGTIPR DLGVGEQITT VSAIDADELQ LVQYQIEAGN ELDLFSLNPN SGVLSLKRSL MDGLGAKVSF HSLRITATDG ENFATPLYIN ITVAASHKLV NLQCEETGVA KMLAEKLLQA NKLHNQGEVE DIFFDSHSVN AHIPQFRSTL PTGIQVKENQ PVGSSVIFMN STDLDTGFNG KLVYAVSGGN EDSCFMIDME TGMLKILSPL DRETTDKYTL NITVYDLGIP QKAAWRLLHV VVVDANDNPP EFLQESYFVE VSEDKEVHSE IIQVEATDKD LGPNGHVTYS ILTDTDTFSI DSVTGVVNIA RPLDRELQHE HSLKIEARDQ AREEPQLFST VVVKVSLEDV NDNPPTFIPP NYRVKVREDL PEGTVIMWLE AHDPDLGQSG QVRYSLLDHG EGNFDVDKLS GAVRIVQQLD FEKKQVYNLT VRAKDKGKPV SLSSTCYVEV EVVDVNENLH PPVFSSFVEK GTVKEDAPVG SLVMTVSAHD EDAGRDGEIR YSIRDGSGVG VFKIGEETGV IETSDRLDRE STSHYWLTVF ATDQGVVPLS SFIEIYIEVE DVNDNAPQTS EPVYYPEIME NSPKDVSVVQ IEAFDPDSSS NDKLMYKITS GNPQGFFSIH PKTGLITTTS RKLDREQQDE HILEVTVTDN GSPPKSTIAR VIVKILDEND NKPQFLQKFY KIRLPEREKP DRERNARREP LYRVIATDKD EGPNAEISYS IEDGNEHGKF FIEPKTGVVS SKRFSAAGEY DILSIKAVDN GRPQKSSTTR LHIEWISKPK QSLEPISFEE SFFTFTVMES DPVAHMIGVI SVEPPGIPLW FDITGGNYDS HFDVDKGTGT IIVAKPLDAE QKSNYNLTVE ATDGTTTILT QVFIKVIDTN DHRPQFSTSK YEVVIPEDTA PETEILQISA VDQDEKNKLI YTLQSSRDPL SLKKFRLDPA TGSLYTSEKL DHEAVSPAHL TVMVRDQDVP VKRNFARIVV NVSDTNDHAP WFTASSYKGR VYESAAVGSV VLQVTALDKD KGKNAEVLYS IESGNIGNIG NSFMIDPVLG SIKTAKELDR SNQAEYDLMV KATDKGSPPM SEITSVRIFV TIADNASPKF TSKEYSVELS ETVSIGSFVG MVTAHSQSSV VYEIKDGNTG DAFDINPHSG TIITQKALDF ETLPIYTLII QGTNMAGLST NTTVLVHLQD ENDNAPVFMQ AEYTGLISES ASINSVVLTD RNVPLVIRAA DADKDSNALL VYHIVEPSVH TYFAIDSSTG AIHTVLSLDY EETSIFHFTV QVHDMGTPRL FAEYAANVTV HVIDINDCPP VFAKPLYEAS LLLPTYKGVK VITVNATDAD SSAFSQLIYS ITEGNIGEKF SMDYKTGALT VQNTTQLRSR YELTVRASDG RFAGLTSVKI NVKESKESHL KFTQDVYSAV VKENSTEAET LAVITAIGSP INEPLFYHIL NPDRRFKISR TSGVLSTTGT PFDREQQEAF DVVVEVIEEH KPSAVAHVVV KVIVEDQNDN APVFVNLPYY AVVKVDTEVG HVIRYVTAVD RDSGRNGEVH YYLKEHHEHF QIGPLGEISL KKQFELDTLN KEYLVTVVAK DGGNPAFSAE VIVPITVMNK AMPVFEKPFY SAEIAESIQV HSPVVHVQAN SPEGLKVFYS ITDGDPFSQF TINFNTGVIN VIAPLDFEAH PAYKLSIRAT DSLTGAHAEV FVDIIVDDIN DNPPVFAQQS YAVTLSEASV IGTSVVQVRA TDSDSEPNRG ISYQMFGNHS KSHDHFHVDS STGLISLLRT LDYEQSRQHT IFVRAVDGGM PTLSSDVIVT VDVTDLNGNP PLFEQQIYEA RISEHAPHGH FVTCVKAYDA DSSDIDKLQY SILSGNDHKH FVIDSATGII TLSNLHRHAL KPFYSLNLSV SDGVFRSSTQ VHVTVIGGNL HSPAFLQNEY EVELAENAPL HTLVMEVKTT DGDSGIYGHV TYHIVNDFAK DRFYINERGQ IFTLEKLDRE TPAEKVISVR LMAKDAGGKV AFCTVNVILT DDNDNAPQFR ATKYEVNIGS SAAKGTSVVK SASDADEGSN ADITYAIEAD SESVKENLEI NKLSGVITTK ESLIGLENEF FTFFVRAVDN GSPSKESVVL VYVKILPPEM QLPKFSEPFY TFTVSEDVPV GTEIDLIRAE HSGTVLYSLV KGNTPESNRD ESFVIDRQSG RLKLEKSLDH ETTKWYQFSI LARCTQDDHE MVASVDVSIQ VKDANDNSPV FESSPYEAFI VENLPGGSRV IQIRASDADS GTNGQVMYSL DQSQSVEVIE SFAINMETGW ITTLKELDHE KRDNYQIKVV ASDHGEKIQL SSTAIVDVTV TDVNDSPPRF TAEIYKGTVS EDDPQGGVIA ILSTTDADSE EINRQVTYFI TGGDPLGQFA VETIQNEWKV YVKKPLDREK RDNYLLTITA TDGTFSSKAI VEVKVLDAND NSPVCEKTLY SDTIPEDVLP GKLIMQISAT DADIRSNAEI TYTLLGSGAE KFKLNPDTGE LKTSTPLDRE EQAVYHLLVR ATDGGGRFCQ ASIVVTLEDV NDNAPEFSAD PYAITVFENT EPGTLLTRVQ ATDADAGLNR KILYSLIDSA DGQFSINELS GIIQLEKPLD RELQAVYTLS LKAVDQGLPR RLTATGTVIV SVLDINDNPP VFEYREYGAT VSEDILVGTE VLQVYAASRD IEANAEITYS IISGNEHGKF SIDSKTGAVF IIENLDYESS HEYYLTVEAT DGGTPSLSDV ATVNVNVTDI NDNTPVFSQD TYTTVISEDA VLEQSVITVM ADDADGPSNS HIHYSIIDGN QGSSFTIDPV RGEVKVTKLL DRETISGYTL TVQASDNGSP PRVNTTTVNI DVSDVNDNAP VFSRGNYSVI IQENKPVGFS VLQLVVTDED SSHNGPPFFF TIVTGNDEKA FEVNPQGVLL TSSAIKRKEK DHYLLQVKVA DNGKPQLSSL TYIDIRVIEE SIYPPAILPL EIFITSSGEE YSGGVIGKIH ATDQDVYDTL TYSLDPQMDN LFSVSSTGGK LIAHKKLDIG QYLLNVSVTD GKFTTVADIT VHIRQVTQEM LNHTIAIRFA NLTPEEFVGD YWRNFQRALR NILGVRRNDI QIVSLQSSEP HPHLDVLLFV EKPGSAQIST KQLLHKINSS VTDIEEIIGV RILNVFQKLC AGLDCPWKFC DEKVSVDESV MSTHSTARLS FVTPRHHRAA VCLCKEGRCP PVHHGCEDDP CPEGSECVSD PWEEKHTCVC PSGRFGQCPG SSSMTLTGNS YVKYRLTENE NKLEMKLTMR LRTYSTHAVV MYARGTDYSI LEIHHGRLQY KFDCGSGPGI VSVQSIQVND GQWHAVALEV NGNYARLVLD QVHTASGTAP GTLKTLNLDN YVFFGGHIRQ QGTRHGRSPQ VGNGFRGCMD SIYLNGQELP LNSKPRSYAH IEESVDVSPG CFLTATEDCA SNPCQNGGVC NPSPAGGYYC KCSALYIGTH CEISVNPCSS NPCLYGGTCV VDNGGFVCQC RGLYTGQRCQ LSPYCKDEPC KNGGTCFDSL DGAVCQCDSG FRGERCQSDI DECSGNPCLH GALCENTHGS YHCNCSHEYR GRHCEDAAPN QYVSTPWNIG LAEGIGIVVF VAGIFLLVVV FVLCRKMISR KKKHQAEPKD KHLGPATAFL QRPYFDSKLN KNIYSDIPPQ VPVRPISYTP SIPSDSRNNL DRNSFEGSAI PEHPEFSTFN PESVHGHRKA VAVCSVAPNL PPPPPSNSPS DSDSIQKPSW DFDYDTKVVD LDPCLSKKPL EEKPSQPYSA RESLSEVQSL SSFQSESCDD NGYHWDTSDW MPSVPLPDIQ EFPNYEVIDE QTPLYSADPN AIDTDYYPGG YDIESDFPPP PEDFPAADEL PPLPPEFSNQ FESIHPPRDM PAAGSLGSSS RNRQRFNLNQ YLPNFYPLDM SEPQTKGTGE NSTCREPHAP YPPGYQRHFE APAVESMPMS VYASTASCSD VSACCEVESE VMMSDYESGD DGHFEEVTIP PLDSQQHTEV