FAIM3_HUMAN » Fas apoptotic inhibitory molecule 3

FAIM3_HUMAN » Fas apoptotic inhibitory molecule 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FAIM3_HUMAN » Fas apoptotic inhibitory molecule 3 » Regulator of Fas-induced apoptosis Toso;
Hydrophobic Thickness 34.8 ± 1.5 Å
Tilt Angle 10 ± 10°
ΔGtransfer -25.1 kcal/mol
ΔGfold -18.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 254-276 (250-279)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 21-123, PDBID: 4NOB, Subunit A, Seq Identity:28%, Immunoglobulin V-set domain

UniProt annotation for FAIM3_HUMAN » Fas apoptotic inhibitory molecule 3
FUNCTION: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

TISSUE SPECIFICITY: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.

INDUCTION: By T-cell activation.

DOMAIN: The Ig-like domain is required for the anti-apoptotic ability.

MISCELLANEOUS: "Toso" is a Japanese liquor drunk on New Year"s day to celebrate long life and eternal youth.

UniProt features for FAIM3_HUMAN » Fas apoptotic inhibitory molecule 3
SIGNAL 1 17 Potential.
CHAIN 18 390 Fas apoptotic inhibitory molecule 3.
DOMAIN 33 105 Ig-like.
DISULFID 37 104 By similarity.
Amino Acid Sequence for FAIM3_HUMAN » Fas apoptotic inhibitory molecule 3
MDFWLWPLYF LPVSGALRIL PEVKVEGELG GSVTIKCPLP EMHVRIYLCR EMAGSGTCGT VVSTTNFIKA EYKGRVTLKQ YPRKNLFLVE VTQLTESDSG VYACGAGMNT DRGKTQKVTL NVHSEYEPSW EEQPMPETPK WFHLPYLFQM PAYASSSKFV TRVTTPAQRG KVPPVHHSSP TTQITHRPRV SRASSVAGDK PRTFLPSTTA SKISALEGLL KPQTPSYNHH TRLHRQRALD YGSQSGREGQ GFHILIPTIL GLFLLALLGL VVKRAVERRK ALSRRARRLA VRMRALESSQ RPRGSPRPRS QNNIYSACPR RARGADAAGT GEAPVPGPGA PLPPAPLQVS ESPWLHAPSL KTSCEYVSLY HQPAAMMEDS DSDDYINVPA