ESAM_HUMAN » Endothelial cell-selective adhesion molecule

ESAM_HUMAN » Endothelial cell-selective adhesion molecule
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ESAM_HUMAN » Endothelial cell-selective adhesion molecule »
Hydrophobic Thickness 32.0 ± 1.4 Å
Tilt Angle 0 ± 2°
ΔGtransfer -43.2 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 250-272 (247-274)
Pathways

Cell adhesion molecules (KEGG)

Hemostasis (Reactome)

Leukocyte transendothelial migration (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 36-150, PDBID: 2OR8, Subunit B, Seq Identity:23%, Immunoglobulin V-set domain

AA: 155-228, PDBID: 1CS6, Subunit A, Seq Identity:26%, Immunoglobulin domain

UniProt annotation for ESAM_HUMAN » Endothelial cell-selective adhesion molecule
FUNCTION: Can mediate aggregation most likely through a homophilic molecular interaction.

SUBUNIT: Interacts with BAIAP1.

TISSUE SPECIFICITY: Highly expressed in endothelial cells.

UniProt features for ESAM_HUMAN » Endothelial cell-selective adhesion molecule
SIGNAL 1 29
CHAIN 30 390 Endothelial cell-selective adhesion molecule.
DOMAIN 30 143 Ig-like V-type.
DOMAIN 153 242 Ig-like C2-type.
DISULFID 174 224 By similarity.
Amino Acid Sequence for ESAM_HUMAN » Endothelial cell-selective adhesion molecule
MISLPGPLVT NLLRFLFLGL SALAPPSRAQ LQLHLPANRL QAVEGGEVVL PAWYTLHGEV SSSQPWEVPF VMWFFKQKEK EDQVLSYING VTTSKPGVSL VYSMPSRNLS LRLEGLQEKD SGPYSCSVNV QDKQGKSRGH SIKTLELNVL VPPAPPSCRL QGVPHVGANV TLSCQSPRSK PAVQYQWDRQ LPSFQTFFAP ALDVIRGSLS LTNLSSSMAG VYVCKAHNEV GTAQCNVTLE VSTGPGAAVV AGAVVGTLVG LGLLAGLVLL YHRRGKALEE PANDIKEDAI APRTLPWPKS SDTISKNGTL SSVTSARALR PPHGPPRPGA LTPTPSLSSQ ALPSPRLPTT DGAHPQPISP IPGGVSSSGL SRMGAVPVMV PAQSQAGSLV