ERV41_YEAST » ER-derived vesicles protein ERV41

ERV41_YEAST » ER-derived vesicles protein ERV41
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
ERV41_YEAST » ER-derived vesicles protein ERV41 »
Hydrophobic Thickness 33.4 ± 3.5 Å
Tilt Angle 5 ± 2°
ΔGtransfer -17.9 kcal/mol
ΔGfold -13.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 22-43 (14-43)
Pathways none
PDB 3zlc (A/B=49-297)
OPM none
Complexes none
Interactions none
Domains

AA: 4-93, PDBID: 3ZLC, Subunit A, Seq Identity:100%, Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

AA: 145-320, PDBID: 3ZLC, Subunit A, Seq Identity:100%, Endoplasmic reticulum vesicle transporter

UniProt annotation for ERV41_YEAST » ER-derived vesicles protein ERV41
FUNCTION: Constituent of COPII-coated endoplasmic reticulum- derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Ile-Leu motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.
UniProt features for ERV41_YEAST » ER-derived vesicles protein ERV41
CHAIN 1 352 ER-derived vesicles protein ERV41.

MOTIF 349 350 Isoleucine-leucine motif.

Amino Acid Sequence for ERV41_YEAST » ER-derived vesicles protein ERV41
MAGLKTFDAF PKTEEQYKKK STKGGLTSLL TYLFLLFIAW TEFGEYFGGY IDQQYVVDSQ VRDTVQINMD IYVNTKCDWL QINVRDQTMD RKLVLEELQL EEMPFFIPYD TKVNDINEII TPELDEILGE AIPAEFREKL DTRSFFDESD PNKAHLPEFN GCHVFGSIPV NRVSGELQIT AKSLGYVASR KAPLEELKFN HVINEFSFGD FYPYIDNPLD NTAQFNQDEP LTTYVYYTSV VPTLFKKLGA EVDTNQYSVN DYRYLYKDVA AKGDKMPGIF FKYNFEPLSI VVSDVRLSFI QFLVRLVAIC SFLVYCASWI FTLLDMALIT IMGPKWSLRY QPDDKTKGIL DR