ERMAP_HUMAN » Erythroid membrane-associated protein

ERMAP_HUMAN » Erythroid membrane-associated protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ERMAP_HUMAN » Erythroid membrane-associated protein » hERMAP; Radin blood group antigen;Scianna blood group antigen;
Hydrophobic Thickness 34.8 ± 3.2 Å
Tilt Angle 3 ± 8°
ΔGtransfer -27.6 kcal/mol
ΔGfold -25.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 156-179 (153-184)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 38-144, PDBID: 1PKO, Subunit A, Seq Identity:42%, Immunoglobulin V-set domain

AA: 240-288, PDBID: 2IWG, Subunit E, Seq Identity:60%, SPRY-associated domain

AA: 292-401, PDBID: 2WL1, Subunit A, Seq Identity:56%, SPRY domain

UniProt annotation for ERMAP_HUMAN » Erythroid membrane-associated protein
FUNCTION: Possible role as a cell-adhesion or receptor molecule of erythroid cells.

TISSUE SPECIFICITY: Expressed in erythroid-enriched bone marrow (at protein level). Highly expressed in bone marrow and to a lower extent in leukocytes, thymus, lymph node and spleen.

DEVELOPMENTAL STAGE: Expressed in fetal liver blood cells (at protein level). Highly expressed in fetal liver.

UniProt features for ERMAP_HUMAN » Erythroid membrane-associated protein
SIGNAL 1 29 Potential.
CHAIN 30 475 Erythroid membrane-associated protein.
DOMAIN 30 140 Ig-like V-type.
DOMAIN 220 418 B30.2/SPRY.
DISULFID 50 126 By similarity.
Amino Acid Sequence for ERMAP_HUMAN » Erythroid membrane-associated protein
MEMASSAGSW LSGCLIPLVF LRLSVHVSGH AGDAGKFHVA LLGGTAELLC PLSLWPGTVP KEVRWLRSPF PQRSQAVHIF RDGKDQDEDL MPEYKGRTVL VRDAQEGSVT LQILDVRLED QGSYRCLIQV GNLSKEDTVI LQVAAPSVGS LSPSAVALAV ILPVLVLLIM VCLCLIWKQR RAKEKLLYEH VTEVDNLLSD HAKEKGKLHK AVKKLRSELK LKRAAANSGW RRARLHFVAV TLDPDTAHPK LILSEDQRCV RLGDRRQPVP DNPQRFDFVV SILGSEYFTT GCHYWEVYVG DKTKWILGVC SESVSRKGKV TASPANGHWL LRQSRGNEYE ALTSPQTSFR LKEPPRCVGI FLDYEAGVIS FYNVTNKSHI FTFTHNFSGP LRPFFEPCLH DGGKNTAPLV ICSELHKSEE SIVPRPEGKG HANGDVSLKV NSSLLPPKAP ELKDIILSLP PDLGPALQEL KAPSF