ERLN1_HUMAN » Erlin-1

ERLN1_HUMAN » Erlin-1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
ERLN1_HUMAN » Erlin-1 » Endoplasmic reticulum lipid raft-associated protein 1;Protein KE04;Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1;SPFH domain-containing protein 1;
Hydrophobic Thickness 29.6 ± 3.3 Å
Tilt Angle 10 ± 6°
ΔGtransfer -19.9 kcal/mol
ΔGfold -14.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 2-23 (2-24)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ERLN2, Complex: ERLN2:ERLN1, PubMed

VCAM1, Complex: VCAM1:ERLN1

Domains

AA: 24-258, PDBID: 4FVF, Subunit A, Seq Identity:19%, SPFH domain / Band 7 family

UniProt annotation for ERLN1_HUMAN » Erlin-1
FUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs).

SUBUNIT: Forms a heteromeric complex with ERLIN2. In complex with ERLIN2, interacts with RNF170.

TISSUE SPECIFICITY: Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine.

UniProt features for ERLN1_HUMAN » Erlin-1
CHAIN 1 346 Erlin-1.
Amino Acid Sequence for ERLN1_HUMAN » Erlin-1
MTQARVLVAA VVGLVAVLLY ASIHKIEEGH LAVYYRGGAL LTSPSGPGYH IMLPFITTFR SVQTTLQTDE VKNVPCGTSG GVMIYIDRIE VVNMLAPYAV FDIVRNYTAD YDKTLIFNKI HHELNQFCSA HTLQEVYIEL FDQIDENLKQ ALQKDLNLMA PGLTIQAVRV TKPKIPEAIR RNFELMEAEK TKLLIAAQKQ KVVEKEAETE RKKAVIEAEK IAQVAKIRFQ QKVMEKETEK RISEIEDAAF LAREKAKADA EYYAAHKYAT SNKHKLTPEY LELKKYQAIA SNSKIYFGSN IPNMFVDSSC ALKYSDIRTG RESSLPSKEA LEPSGENVIQ NKESTG