ERL2_ARATH » LRR receptor-like serine/threonine-protein kinase ERL2

ERL2_ARATH » LRR receptor-like serine/threonine-protein kinase ERL2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ERL2_ARATH » LRR receptor-like serine/threonine-protein kinase ERL2 » Protein ERECTA-like kinase 2;
Hydrophobic Thickness 35.2 ± 3.2 Å
Tilt Angle 33 ± 6°
ΔGtransfer -30.3 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 580-607 (578-611)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 28-69, PDBID: 4M7E, Subunit D, Seq Identity:38%, Leucine rich repeat N-terminal domain

AA: 145-188, PDBID: 3RGX, Subunit A, Seq Identity:38%, Leucine Rich repeats (2 copies)

AA: 239-257, PDBID: 4J0M, Subunit B, Seq Identity:57%, Leucine Rich repeat

AA: 432-492, PDBID: 3WPE, Subunit A, Seq Identity:39%, Leucine rich repeat

AA: 651-916, PDBID: 2RIO, Subunit B, Seq Identity:33%, Protein kinase domain

UniProt annotation for ERL2_ARATH » LRR receptor-like serine/threonine-protein kinase ERL2
FUNCTION: Receptor kinase that regulates inflorescence architecture and organ shape as well as stomatal patterning, including density and clustering, together with ERL1 and ER.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

TISSUE SPECIFICITY: Mostly expressed in developing organs, including bud clusters, flowers, siliques and young rosettes. Also detected in mature aboveground organs, such as leaves, stems and pedicels, but barely in roots.

DEVELOPMENTAL STAGE: At the vegetative stage, strongly expressed in the shoot meristem, leaf primordia and juvenile leaves. At the reproductive stage, localized in the young developing flowers.

UniProt features for ERL2_ARATH » LRR receptor-like serine/threonine-protein kinase ERL2
SIGNAL 1 27 Potential.
CHAIN 28 967 LRR receptor-like serine/threonine- protein kinase ERL2.
REPEAT 74 97 LRR 1.
REPEAT 98 120 LRR 2.
REPEAT 122 145 LRR 3.
REPEAT 146 166 LRR 4.
REPEAT 170 192 LRR 5.
REPEAT 194 216 LRR 6.
REPEAT 218 240 LRR 7.
REPEAT 242 261 LRR 8.
REPEAT 265 287 LRR 9.
REPEAT 289 311 LRR 10.
REPEAT 313 335 LRR 11.
REPEAT 337 359 LRR 12.
REPEAT 361 382 LRR 13.
REPEAT 385 406 LRR 14.
REPEAT 409 431 LRR 15.
REPEAT 433 456 LRR 16.
REPEAT 457 479 LRR 17.
REPEAT 481 503 LRR 18.
REPEAT 505 527 LRR 19.
REPEAT 529 550 LRR 20.
DOMAIN 651 921 Protein kinase.
ACT_SITE 776 776 Proton acceptor (By similarity).
Amino Acid Sequence for ERL2_ARATH » LRR receptor-like serine/threonine-protein kinase ERL2
MRRIETMKGL FFCLGMVVFM LLGSVSPMNN EGKALMAIKA SFSNVANMLL DWDDVHNHDF CSWRGVFCDN VSLNVVSLNL SNLNLGGEIS SALGDLMNLQ SIDLQGNKLG GQIPDEIGNC VSLAYVDFST NLLFGDIPFS ISKLKQLEFL NLKNNQLTGP IPATLTQIPN LKTLDLARNQ LTGEIPRLLY WNEVLQYLGL RGNMLTGTLS PDMCQLTGLW YFDVRGNNLT GTIPESIGNC TSFEILDVSY NQITGVIPYN IGFLQVATLS LQGNKLTGRI PEVIGLMQAL AVLDLSDNEL TGPIPPILGN LSFTGKLYLH GNKLTGQIPP ELGNMSRLSY LQLNDNELVG KIPPELGKLE QLFELNLANN NLVGLIPSNI SSCAALNQFN VHGNFLSGAV PLEFRNLGSL TYLNLSSNSF KGKIPAELGH IINLDTLDLS GNNFSGSIPL TLGDLEHLLI LNLSRNHLNG TLPAEFGNLR SIQIIDVSFN FLAGVIPTEL GQLQNINSLI LNNNKIHGKI PDQLTNCFSL ANLNISFNNL SGIIPPMKNF TRFSPASFFG NPFLCGNWVG SICGPSLPKS QVFTRVAVIC MVLGFITLIC MIFIAVYKSK QQKPVLKGSS KQPEGSTKLV ILHMDMAIHT FDDIMRVTEN LDEKYIIGYG ASSTVYKCTS KTSRPIAIKR IYNQYPSNFR EFETELETIG SIRHRNIVSL HGYALSPFGN LLFYDYMENG SLWDLLHGPG KKVKLDWETR LKIAVGAAQG LAYLHHDCTP RIIHRDIKSS NILLDGNFEA RLSDFGIAKS IPATKTYAST YVLGTIGYID PEYARTSRLN EKSDIYSFGI VLLELLTGKK AVDNEANLHQ MILSKADDNT VMEAVDAEVS VTCMDSGHIK KTFQLALLCT KRNPLERPTM QEVSRVLLSL VPSPPPKKLP SPAKVQEGEE RRESHSSDTT TPQWFVQFRE DISKSSL