ERL1_ARATH » LRR receptor-like serine/threonine-protein kinase ERL1

ERL1_ARATH » LRR receptor-like serine/threonine-protein kinase ERL1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ERL1_ARATH » LRR receptor-like serine/threonine-protein kinase ERL1 » Protein ERECTA-like kinase 1;
Hydrophobic Thickness 27.2 ± 1.6 Å
Tilt Angle 1 ± 1°
ΔGtransfer -39.4 kcal/mol
ΔGfold -19.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 584-605 (584-610)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BET12, Complex: ERL1:BET12

BETL2, Complex: ERL1:BETL2

C71B6, Complex: ERL1:C71B6

CASP, Complex: CASP:ERL1

ERECT, Complex: ERECT:ERL1

GOS12, Complex: GOS12:ERL1

LRK32, Complex: LRK32:ERL1

MEM12, Complex: MEM12:ERL1

NPS11, Complex: NPS11:ERL1

OST48, Complex: OST48:ERL1

P24DA, Complex: P24DA:ERL1

PAM74, Complex: ERL1:PAM74

PHF1, Complex: PHF1:ERL1

SEC22, Complex: SEC22:ERL1

TMM, Complex: ERL1:TMM

UBC32, Complex: ERL1:UBC32

UBC34, Complex: ERL1:UBC34

VA722, Complex: VA722:ERL1

VAP21, Complex: ERL1:VAP21

VTI12, Complex: VTI12:ERL1

WAK3, Complex: ERL1:WAK3

Domains

AA: 26-67, PDBID: 4M7E, Subunit D, Seq Identity:38%, Leucine rich repeat N-terminal domain

AA: 119-179, PDBID: 4MN8, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 237-255, PDBID: 4J0M, Subunit B, Seq Identity:57%, Leucine Rich repeat

AA: 430-490, PDBID: 3WPE, Subunit A, Seq Identity:42%, Leucine rich repeat

AA: 648-913, PDBID: 4OA2, Subunit A, Seq Identity:39%, Protein kinase domain

UniProt annotation for ERL1_ARATH » LRR receptor-like serine/threonine-protein kinase ERL1
FUNCTION: Receptor kinase that regulates inflorescence architecture and organ shape as well as stomatal patterning, including density and clustering, together with ER and ERL2. Redundantly involved with ER in procambial development regulation. Forms a functional ligand-receptor pair with EPF1 (AC Q8S8I4) (PubMed).

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBUNIT: Homodimer and heterodimer with ERECTA. Interacts with EPF1 and EPF2.

TISSUE SPECIFICITY: Mostly expressed in developing organs, including bud clusters, flowers, siliques and young rosettes. Also detected in mature aboveground organs, such as leaves, stems and pedicels, but barely in roots.

DEVELOPMENTAL STAGE: At the vegetative stage, strongly expressed in the shoot meristem, leaf primordia and juvenile leaves. At the reproductive stage, localized in the young developing flowers. Expressed in inflorescence meristem and is up-regulated during flower initiation and formation of flower organs. Also found in cells that differentiate into pedicels.

DOMAIN: The kinase domain is not required for ligand binding.

UniProt features for ERL1_ARATH » LRR receptor-like serine/threonine-protein kinase ERL1
SIGNAL 1 25 Potential.
CHAIN 26 966 LRR receptor-like serine/threonine- protein kinase ERL1.
REPEAT 40 63 LRR 1.
REPEAT 75 94 LRR 2.
REPEAT 95 118 LRR 3.
REPEAT 120 142 LRR 4.
REPEAT 143 166 LRR 5.
REPEAT 168 190 LRR 6.
REPEAT 192 214 LRR 7.
REPEAT 215 238 LRR 8.
REPEAT 239 261 LRR 9.
REPEAT 262 285 LRR 10.
REPEAT 286 311 LRR 11.
REPEAT 313 333 LRR 12.
REPEAT 334 357 LRR 13.
REPEAT 359 381 LRR 14.
REPEAT 383 404 LRR 15.
REPEAT 405 429 LRR 16.
REPEAT 431 453 LRR 17.
REPEAT 454 476 LRR 18.
REPEAT 478 500 LRR 19.
REPEAT 501 525 LRR 20.
REPEAT 527 550 LRR 21.
DOMAIN 648 921 Protein kinase.
ACT_SITE 773 773 Proton acceptor (By similarity).
Amino Acid Sequence for ERL1_ARATH » LRR receptor-like serine/threonine-protein kinase ERL1
MKEKMQRMVL SLAMVGFMVF GVASAMNNEG KALMAIKGSF SNLVNMLLDW DDVHNSDLCS WRGVFCDNVS YSVVSLNLSS LNLGGEISPA IGDLRNLQSI DLQGNKLAGQ IPDEIGNCAS LVYLDLSENL LYGDIPFSIS KLKQLETLNL KNNQLTGPVP ATLTQIPNLK RLDLAGNHLT GEISRLLYWN EVLQYLGLRG NMLTGTLSSD MCQLTGLWYF DVRGNNLTGT IPESIGNCTS FQILDISYNQ ITGEIPYNIG FLQVATLSLQ GNRLTGRIPE VIGLMQALAV LDLSDNELVG PIPPILGNLS FTGKLYLHGN MLTGPIPSEL GNMSRLSYLQ LNDNKLVGTI PPELGKLEQL FELNLANNRL VGPIPSNISS CAALNQFNVH GNLLSGSIPL AFRNLGSLTY LNLSSNNFKG KIPVELGHII NLDKLDLSGN NFSGSIPLTL GDLEHLLILN LSRNHLSGQL PAEFGNLRSI QMIDVSFNLL SGVIPTELGQ LQNLNSLILN NNKLHGKIPD QLTNCFTLVN LNVSFNNLSG IVPPMKNFSR FAPASFVGNP YLCGNWVGSI CGPLPKSRVF SRGALICIVL GVITLLCMIF LAVYKSMQQK KILQGSSKQA EGLTKLVILH MDMAIHTFDD IMRVTENLNE KFIIGYGASS TVYKCALKSS RPIAIKRLYN QYPHNLREFE TELETIGSIR HRNIVSLHGY ALSPTGNLLF YDYMENGSLW DLLHGSLKKV KLDWETRLKI AVGAAQGLAY LHHDCTPRII HRDIKSSNIL LDENFEAHLS DFGIAKSIPA SKTHASTYVL GTIGYIDPEY ARTSRINEKS DIYSFGIVLL ELLTGKKAVD NEANLHQLIL SKADDNTVME AVDPEVTVTC MDLGHIRKTF QLALLCTKRN PLERPTMLEV SRVLLSLVPS LQVAKKLPSL DHSTKKLQQE NEVRNPDAEA SQWFVQFREV ISKSSI