EREG_HUMAN » Proepiregulin

EREG_HUMAN » Proepiregulin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EREG_HUMAN » Proepiregulin »
Hydrophobic Thickness 34.4 ± 3.8 Å
Tilt Angle 29 ± 3°
ΔGtransfer -30.0 kcal/mol
ΔGfold -23.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 116-141 (116-151)
Pathways

ErbB signaling pathway (KEGG)

Immune System (Reactome)

Signal Transduction (Reactome)

PDB 1k36 (63-108), 1k37 (63-108)
OPM none
Complexes none
Interactions

EGFR, Complex: EGFR:EREG, PubMed

ERBB4, Complex: ERBB4:EREG, PubMed

Domains none
UniProt annotation for EREG_HUMAN » Proepiregulin
FUNCTION: Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.

SUBUNIT: Interacts with EGFR and ERBB4.

TISSUE SPECIFICITY: In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.

UniProt features for EREG_HUMAN » Proepiregulin
SIGNAL 1 29 Potential.
CHAIN 30 169 Proepiregulin.
PROPEP 30 59 Potential.
CHAIN 60 108 Epiregulin.
PROPEP 109 169 Removed in mature form (By similarity).
DOMAIN 64 104 EGF-like.
DISULFID 68 81
DISULFID 76 92
DISULFID 94 103
Amino Acid Sequence for EREG_HUMAN » Proepiregulin
MTAGRRMEML CAGRVPALLL CLGFHLLQAV LSTTVIPSCI PGESSDNCTA LVQTEDNPRV AQVSITKCSS DMNGYCLHGQ CIYLVDMSQN YCRCEVGYTG VRCEHFFLTV HQPLSKEYVA LTVILIILFL ITVVGSTYYF CRWYRNRKSK EPKKEYERVT SGDPELPQV