EPHB6_HUMAN » Ephrin type-B receptor 6

EPHB6_HUMAN » Ephrin type-B receptor 6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EPHB6_HUMAN » Ephrin type-B receptor 6 » HEP;Tyrosine-protein kinase-defective receptor EPH-6;
Hydrophobic Thickness 39.6 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -54.6 kcal/mol
ΔGfold -28.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 578-605 (575-609)
Pathways

Axon guidance (KEGG)

PDB none
OPM none
Complexes none
Interactions

EFNB2, Complex: EPHB6:EFNB2, PubMed

EPHB1, Complex: EPHB1:EPHB6, PubMed

EPHB4, Complex: EPHB6:EPHB4, PubMed

Domains

AA: 34-232, PDBID: 1KGY, Subunit A, Seq Identity:42%, Ephrin receptor ligand binding domain

AA: 304-346, Putative ephrin-receptor like

AA: 371-471, PDBID: 4BK4, Subunit A, Seq Identity:39%, Fibronectin type III domain

AA: 489-572, PDBID: 2DJS, Subunit A, Seq Identity:51%, Fibronectin type III domain

AA: 596-667, PDBID: 3ZFM, Subunit A, Seq Identity:34%, Ephrin type-A receptor 2 transmembrane domain

AA: 670-915, PDBID: 3ZFX, Subunit I, Seq Identity:52%, Protein tyrosine kinase

AA: 945-1010, PDBID: 3H8M, Subunit A, Seq Identity:42%, SAM domain (Sterile alpha motif)

UniProt annotation for EPHB6_HUMAN » Ephrin type-B receptor 6
FUNCTION: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

SUBUNIT: Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner.

TISSUE SPECIFICITY: Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.

DOMAIN: The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2.

UniProt features for EPHB6_HUMAN » Ephrin type-B receptor 6
SIGNAL 1 31
CHAIN 32 1021 Ephrin type-B receptor 6.
DOMAIN 33 237 Eph LBD.
DOMAIN 369 478 Fibronectin type-III 1.
DOMAIN 488 579 Fibronectin type-III 2.
DOMAIN 670 919 Protein kinase.
DOMAIN 948 1012 SAM.
MOTIF 1019 1021 PDZ-binding (Potential).
Amino Acid Sequence for EPHB6_HUMAN » Ephrin type-B receptor 6
MVCSLWVLLL VSSVLALEEV LLDTTGETSE IGWLTYPPGG WDEVSVLDDQ RRLTRTFEAC HVAGAPPGTG QDNWLQTHFV ERRGAQRAHI RLHFSVRACS SLGVSGGTCR ETFTLYYRQA EEPDSPDSVS SWHLKRWTKV DTIAADESFP SSSSSSSSSS SAAWAVGPHG AGQRAGLQLN VKERSFGPLT QRGFYVAFQD TGACLALVAV RLFSYTCPAV LRSFASFPET QASGAGGASL VAAVGTCVAH AEPEEDGVGG QAGGSPPRLH CNGEGKWMVA VGGCRCQPGY QPARGDKACQ ACPRGLYKSS AGNAPCSPCP ARSHAPNPAA PVCPCLEGFY RASSDPPEAP CTGPPSAPQE LWFEVQGSAL MLHWRLPREL GGRGDLLFNV VCKECEGRQE PASGGGGTCH RCRDEVHFDP RQRGLTESRV LVGGLRAHVP YILEVQAVNG VSELSPDPPQ AAAINVSTSH EVPSAVPVVH QVSRASNSIT VSWPQPDQTN GNILDYQLRY YDQAEDESHS FTLTSETNTA TVTQLSPGHI YGFQVRARTA AGHGPYGGKV YFQTLPQGEL SSQLPERLSL VIGSILGALA FLLLAAITVL AVVFQRKRRG TGYTEQLQQY SSPGLGVKYY IDPSTYEDPC QAIRELAREV DPAYIKIEEV IGTGSFGEVR QGRLQPRGRR EQTVAIQALW AGGAESLQMT FLGRAAVLGQ FQHPNILRLE GVVTKSRPLM VLTEFMELGP LDSFLRQREG QFSSLQLVAM QRGVAAAMQY LSSFAFVHRS LSAHSVLVNS HLVCKVARLG HSPQGPSCLL RWAAPEVIAH GKHTTSSDVW SFGILMWEVM SYGERPYWDM SEQEVLNAIE QEFRLPPPPG CPPGLHLLML DTWQKDRARR PHFDQLVAAF DKMIRKPDTL QAGGDPGERP SQALLTPVAL DFPCLDSPQA WLSAIGLECY QDNFSKFGLC TFSDVAQLSL EDLPALGITL AGHQKKLLHH IQLLQQHLRQ QGSVEV