EPHAA_HUMAN » Ephrin type-A receptor 10

EPHAA_HUMAN » Ephrin type-A receptor 10
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EPHAA_HUMAN » Ephrin type-A receptor 10 »
Hydrophobic Thickness 29.2 ± 2.0 Å
Tilt Angle 0 ± 3°
ΔGtransfer -34.4 kcal/mol
ΔGfold -16.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 564-589 (562-591)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 36-211, PDBID: 3NRU, Subunit G, Seq Identity:72%, Ephrin receptor ligand binding domain

AA: 339-436, PDBID: 2X10, Subunit A, Seq Identity:38%, Fibronectin type III domain

AA: 458-537, PDBID: 1X5L, Subunit A, Seq Identity:36%, Fibronectin type III domain

AA: 566-642, PDBID: 2GSF, Subunit A, Seq Identity:36%, Ephrin type-A receptor 2 transmembrane domain

AA: 645-900, PDBID: 2R2P, Subunit A, Seq Identity:49%, Protein tyrosine kinase

AA: 932-995, PDBID: 2QKQ, Subunit B, Seq Identity:45%, SAM domain (Sterile alpha motif)

UniProt annotation for EPHAA_HUMAN » Ephrin type-A receptor 10
FUNCTION: Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

TISSUE SPECIFICITY: Mainly expressed in testis.

DOMAIN: The protein kinase domain is predicted to be catalytically inactive.

UniProt features for EPHAA_HUMAN » Ephrin type-A receptor 10
SIGNAL 1 33 Potential.
CHAIN 34 1008 Ephrin type-A receptor 10.
DOMAIN 35 216 Eph LBD.
DOMAIN 337 443 Fibronectin type-III 1.
DOMAIN 454 552 Fibronectin type-III 2.
DOMAIN 645 900 Protein kinase.
DOMAIN 933 997 SAM.
Amino Acid Sequence for EPHAA_HUMAN » Ephrin type-A receptor 10
METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW TALPSNGWEE ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR IFVELQFTLR DCSSIPGAAG TCKETFNVYY LETEADLGRG RPRLGGSRPR KIDTIAADES FTQGDLGERK MKLNTEVREI GPLSRRGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR SPLVLRLRWL PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP RQAGLRERAA TLLHLRPGAR YTVRVAALNG VSGPAAAAGT TYAQVTVSTG PGAPWEEGEI RRDRVEPQSV SLSWREPIPA GAPGANDTEY EIRYYEKGQS EQAYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA QSFNPSIEVQ TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS LGGGRFGELC CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ FDHSHIVRLE GVVTRGSTLM IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL LPGLASAMKY LSEMGYVHRG LAARHVLVSS DLVCKISGFG RGPRDRSEAV YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM AFGERPYWDM SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGER PRFSQIHSIL SKMVQDPEPP KCALTTCPRP PTPLADRAFS TFPSFGSVGA WLEALDLCRY KDSFAAAGYG SLEAVAEMTA QDLVSLGISL AEHREALLSG ISALQARVLQ LQGQGVQV