EPHA6_HUMAN » Ephrin type-A receptor 6

EPHA6_HUMAN » Ephrin type-A receptor 6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EPHA6_HUMAN » Ephrin type-A receptor 6 » EPH homology kinase 2;EHK-2; EPH-like kinase 12;EK12;
Hydrophobic Thickness 33.2 ± 1.4 Å
Tilt Angle 0 ± 4°
ΔGtransfer -48.1 kcal/mol
ΔGfold -21.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 545-571 (542-571)
Pathways

Axon guidance (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 35-207, PDBID: 4L0P, Subunit A, Seq Identity:76%, Ephrin receptor ligand binding domain

AA: 333-427, PDBID: 4BK4, Subunit A, Seq Identity:49%, Fibronectin type III domain

AA: 441-527, PDBID: 2DJS, Subunit A, Seq Identity:43%, Fibronectin type III domain

AA: 550-628, PDBID: 2REI, Subunit A, Seq Identity:45%, Ephrin type-A receptor 2 transmembrane domain

AA: 631-729, PDBID: 2R2P, Subunit A, Seq Identity:83%, Protein tyrosine kinase

AA: 737-930, PDBID: 4L68, Subunit B, Seq Identity:40%, Protein tyrosine kinase

AA: 961-1023, PDBID: 1SGG, Subunit A, Seq Identity:52%, SAM domain (Sterile alpha motif)

UniProt annotation for EPHA6_HUMAN » Ephrin type-A receptor 6
FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

SUBUNIT: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).

TISSUE SPECIFICITY: Expressed in brain and testis.

UniProt features for EPHA6_HUMAN » Ephrin type-A receptor 6
SIGNAL 1 22 Potential.
CHAIN 23 1035 Ephrin type-A receptor 6.
DOMAIN 33 211 Eph LBD.
DOMAIN 330 434 Fibronectin type-III 1.
DOMAIN 438 533 Fibronectin type-III 2.
DOMAIN 630 943 Protein kinase.
DOMAIN 960 1024 SAM.
MOTIF 1033 1035 PDZ-binding (Potential).
ACT_SITE 797 797 Proton acceptor (By similarity).
Amino Acid Sequence for EPHA6_HUMAN » Ephrin type-A receptor 6
MGGCEVREFL LQFGFFLPLL TAWPGDCSHV SNQVVLLDTT TVLGELGWKT YPLNGWDAIT EMDEHNRPIH TYQVCNVMEP NQNNWLRTNW ISRDAAQKIY VEMKFTLRDC NSIPWVLGTC KETFNLFYME SDESHGIKFK PNQYTKIDTI AADESFTQMD LGDRILKLNT EIREVGPIER KGFYLAFQDI GACIALVSVR VFYKKCPFTV RNLAMFPDTI PRVDSSSLVE VRGSCVKSAE ERDTPKLYCG ADGDWLVPLG RCICSTGYEE IEGSCHACRP GFYKAFAGNT KCSKCPPHSL TYMEATSVCQ CEKGYFRAEK DPPSMACTGP PSAPRNVVFN INETALILEW SPPSDTGGRK DLTYSVICKK CGLDTSQCED CGGGLRFIPR HTGLINNSVI VLDFVSHVNY TFEIEAMNGV SELSFSPKPF TAITVTTDHD APSLIGMMRK DWASQNSIAL SWQAPAFSNG AILDYEIKYY EKEHEQLTYS STRSKAPSVI ITGLKPATKY VFHIRVRTAT GYSGYSQKFE FETGDEASDM AAEQGQILVI ATAAVGGFTL LVILTLFFLI TGRCQWYIKA KMKSEEKRRN HLQNGHCKFP GIKTYIDPDT YEDPSLAVHE FAKEIDPSRI RIERVIGAGE FGEVCSGRLK TPGKREIPVA IKTLKGGHMD RQRRDFLREA SIMGQFDHPN IIRLEGVVTK SSFPAIGVEA FCPSFLRAGF LNSIQAPHPV PGGGSLPPRI PAGRPVMIVV EYMENGSLDS FLRKHDGHFT VIQLVGMLRG IASGMKYLSD MGYVHRDLAA RNILVNSNLV CKVSDFGLSR VLEDDPEAAY TTTGGKIPIR WTAPEAIAYR KFSSASDAWS YGIVMWEVMS YGERPYWEMS NQDVILSIEE GYRLPAPMGC PASLHQLMLH CWQKERNHRP KFTDIVSFLD KLIRNPSALH TLVEDILVMP ESPGEVPEYP LFVTVGDWLD SIKMGQYKNN FVAAGFTTFD LISRMSIEDI RRIGVILIGH QRRIVSSIQT LRLHMMHIQE KGFHV