EPHA5_HUMAN » Ephrin type-A receptor 5

EPHA5_HUMAN » Ephrin type-A receptor 5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EPHA5_HUMAN » Ephrin type-A receptor 5 » Brain-specific kinase;EPH homology kinase 1;EHK-1; EPH-like kinase 7;EK7; hEK7;
Hydrophobic Thickness 31.2 ± 3.6 Å
Tilt Angle 1 ± 1°
ΔGtransfer -37.6 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 571-594 (571-595)
Pathways

Axon guidance (KEGG)

PDB 4et7 (59-235), 2r2p (653-939)
OPM none
Complexes none
Interactions none
Domains

AA: 61-233, PDBID: 4ET7, Subunit A, Seq Identity:100%, Ephrin receptor ligand binding domain

AA: 359-453, PDBID: 4BK4, Subunit A, Seq Identity:56%, Fibronectin type III domain

AA: 470-552, PDBID: 1X5L, Subunit A, Seq Identity:53%, Fibronectin type III domain

AA: 574-672, PDBID: 2R2P, Subunit A, Seq Identity:100%, Ephrin type-A receptor 2 transmembrane domain

AA: 675-932, PDBID: 2R2P, Subunit A, Seq Identity:100%, Protein tyrosine kinase

AA: 964-1027, PDBID: 2QKQ, Subunit B, Seq Identity:59%, SAM domain (Sterile alpha motif)

UniProt annotation for EPHA5_HUMAN » Ephrin type-A receptor 5
FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion (By similarity).

CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

SUBUNIT: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).

TISSUE SPECIFICITY: Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.

UniProt features for EPHA5_HUMAN » Ephrin type-A receptor 5
SIGNAL 1 24 Potential.
CHAIN 25 1037 Ephrin type-A receptor 5.
DOMAIN 60 238 Eph LBD.
DOMAIN 357 459 Fibronectin type-III 1.
DOMAIN 469 559 Fibronectin type-III 2.
DOMAIN 675 936 Protein kinase.
DOMAIN 965 1029 SAM.
MOTIF 1035 1037 PDZ-binding (Potential).
ACT_SITE 800 800 Proton acceptor (By similarity).
Amino Acid Sequence for EPHA5_HUMAN » Ephrin type-A receptor 5
MRGSGPRGAG RRRPPSGGGD TPITPASLAG CYSAPRRAPL WTCLLLCAAL RTLLASPSNE VNLLDSRTVM GDLGWIAFPK NGWEEIGEVD ENYAPIHTYQ VCKVMEQNQN NWLLTSWISN EGASRIFIEL KFTLRDCNSL PGGLGTCKET FNMYYFESDD QNGRNIKENQ YIKIDTIAAD ESFTELDLGD RVMKLNTEVR DVGPLSKKGF YLAFQDVGAC IALVSVRVYY KKCPSVVRHL AVFPDTITGA DSSQLLEVSG SCVNHSVTDE PPKMHCSAEG EWLVPIGKCM CKAGYEEKNG TCQVCRPGFF KASPHIQSCG KCPPHSYTHE EASTSCVCEK DYFRRESDPP TMACTRPPSA PRNAISNVNE TSVFLEWIPP ADTGGRKDVS YYIACKKCNS HAGVCEECGG HVRYLPRQSG LKNTSVMMVD LLAHTNYTFE IEAVNGVSDL SPGARQYVSV NVTTNQAAPS PVTNVKKGKI AKNSISLSWQ EPDRPNGIIL EYEIKYFEKD QETSYTIIKS KETTITAEGL KPASVYVFQI RARTAAGYGV FSRRFEFETT PVFAASSDQS QIPVIAVSVT VGVILLAVVI GVLLSGSCCE CGCGRASSLC AVAHPSLIWR CGYSKAKQDP EEEKMHFHNG HIKLPGVRTY IDPHTYEDPN QAVHEFAKEI EASCITIERV IGAGEFGEVC SGRLKLPGKR ELPVAIKTLK VGYTEKQRRD FLGEASIMGQ FDHPNIIHLE GVVTKSKPVM IVTEYMENGS LDTFLKKNDG QFTVIQLVGM LRGISAGMKY LSDMGYVHRD LAARNILINS NLVCKVSDFG LSRVLEDDPE AAYTTRGGKI PIRWTAPEAI AFRKFTSASD VWSYGIVMWE VVSYGERPYW EMTNQDVIKA VEEGYRLPSP MDCPAALYQL MLDCWQKERN SRPKFDEIVN MLDKLIRNPS SLKTLVNASC RVSNLLAEHS PLGSGAYRSV GEWLEAIKMG RYTEIFMENG YSSMDAVAQV TLEDLRRLGV TLVGHQKKIM NSLQEMKVQL VNGMVPL