EPHA1_HUMAN » Ephrin type-A receptor 1

EPHA1_HUMAN » Ephrin type-A receptor 1
Magnify EPHA1_HUMAN » Ephrin type-A receptor 1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EPHA1_HUMAN » Ephrin type-A receptor 1 » hEpha1; EPH tyrosine kinase;EPH tyrosine kinase 1;Erythropoietin-producing hepatoma receptor;Tyrosine-protein kinase receptor EPH;
Hydrophobic Thickness 32.4 ± 2.0 Å
Tilt Angle 2 ± 5°
ΔGtransfer -45.0 kcal/mol
ΔGfold -21.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 547-569 (545-574)
Pathways

Axon guidance (KEGG)

PDB 3hil (911-974), 3kka (911-974), 2k1k (A/B=536-573), 2k1l (A/B=536-573)
OPM 2k1k, 2k1l
Complexes

EPHA1:EPHA1_HUMAN

Interactions

ALK, Complex: EPHA1:ALK, PubMed

EPHA1, Complex: Transmembrane homodimer of receptor tyrosine kinase EphA1, PDBID: 2K1K

Domains

AA: 28-204, PDBID: 2X10, Subunit A, Seq Identity:54%, Ephrin receptor ligand binding domain

AA: 334-431, PDBID: 2X10, Subunit A, Seq Identity:41%, Fibronectin type III domain

AA: 548-621, PDBID: 2K1K, Subunit B, Seq Identity:100%, Ephrin type-A receptor 2 transmembrane domain

AA: 624-880, PDBID: 2GSF, Subunit A, Seq Identity:51%, Protein tyrosine kinase

AA: 911-975, PDBID: 3HIL, Subunit B, Seq Identity:100%, SAM domain (Sterile alpha motif)

UniProt annotation for EPHA1_HUMAN » Ephrin type-A receptor 1
FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

SUBUNIT: Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1.

TISSUE SPECIFICITY: Overexpressed in several carcinomas.

UniProt features for EPHA1_HUMAN » Ephrin type-A receptor 1
SIGNAL 1 25 Potential.
CHAIN 26 976 Ephrin type-A receptor 1.
DOMAIN 27 209 Eph LBD.
DOMAIN 332 437 Fibronectin type-III 1.
DOMAIN 446 535 Fibronectin type-III 2.
DOMAIN 624 884 Protein kinase.
DOMAIN 913 976 SAM.
MOTIF 974 976 PDZ-binding (Potential).
ACT_SITE 749 749 Proton acceptor (By similarity).
Amino Acid Sequence for EPHA1_HUMAN » Ephrin type-A receptor 1
MERRWPLGLG LVLLLCAPLP PGARAKEVTL MDTSKAQGEL GWLLDPPKDG WSEQQQILNG TPLYMYQDCP MQGRRDTDHW LRSNWIYRGE EASRVHVELQ FTVRDCKSFP GGAGPLGCKE TFNLLYMESD QDVGIQLRRP LFQKVTTVAA DQSFTIRDLA SGSVKLNVER CSLGRLTRRG LYLAFHNPGA CVALVSVRVF YQRCPETLNG LAQFPDTLPG PAGLVEVAGT CLPHARASPR PSGAPRMHCS PDGEWLVPVG RCHCEPGYEE GGSGEACVAC PSGSYRMDMD TPHCLTCPQQ STAESEGATI CTCESGHYRA PGEGPQVACT GPPSAPRNLS FSASGTQLSL RWEPPADTGG RQDVRYSVRC SQCQGTAQDG GPCQPCGVGV HFSPGARGLT TPAVHVNGLE PYANYTFNVE AQNGVSGLGS SGHASTSVSI SMGHAESLSG LSLRLVKKEP RQLELTWAGS RPRSPGANLT YELHVLNQDE ERYQMVLEPR VLLTELQPDT TYIVRVRMLT PLGPGPFSPD HEFRTSPPVS RGLTGGEIVA VIFGLLLGAA LLLGILVFRS RRAQRQRQQR QRDRATDVDR EDKLWLKPYV DLQAYEDPAQ GALDFTRELD PAWLMVDTVI GEGEFGEVYR GTLRLPSQDC KTVAIKTLKD TSPGGQWWNF LREATIMGQF SHPHILHLEG VVTKRKPIMI ITEFMENGAL DAFLREREDQ LVPGQLVAML QGIASGMNYL SNHNYVHRDL AARNILVNQN LCCKVSDFGL TRLLDDFDGT YETQGGKIPI RWTAPEAIAH RIFTTASDVW SFGIVMWEVL SFGDKPYGEM SNQEVMKSIE DGYRLPPPVD CPAPLYELMK NCWAYDRARR PHFQKLQAHL EQLLANPHSL RTIANFDPRV TLRLPSLSGS DGIPYRTVSE WLESIRMKRY ILHFHSAGLD TMECVLELTA EDLTQMGITL PGHQKRILCS IQGFKD