EPCR_HUMAN » Endothelial protein C receptor

EPCR_HUMAN » Endothelial protein C receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EPCR_HUMAN » Endothelial protein C receptor » Activated protein C receptor;APC receptor; Endothelial cell protein C receptor;
Hydrophobic Thickness 35.2 ± 3.6 Å
Tilt Angle 18 ± 13°
ΔGtransfer -23.6 kcal/mol
ΔGfold -16.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 208-233 (203-237)
Pathways none
PDB 1l8j (18-210), 1lqv (A/B=18-210), 3jtc (A/B=18-210), 4v3d (B/D=25-194), 4v3e (B=25-195)
OPM 1lqv
Complexes none
Interactions none
Domains

AA: 1-199, PDBID: 1L8J, Subunit A, Seq Identity:100%, MHC-I family domain

UniProt annotation for EPCR_HUMAN » Endothelial protein C receptor
FUNCTION: Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

TISSUE SPECIFICITY: Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

UniProt features for EPCR_HUMAN » Endothelial protein C receptor
SIGNAL 1 17 Potential.
CHAIN 18 238 Endothelial protein C receptor.
DISULFID 118 186
Amino Acid Sequence for EPCR_HUMAN » Endothelial protein C receptor
MLTTLLPILL LSGWAFCSQD ASDGLQRLHM LQISYFRDPY HVWYQGNASL GGHLTHVLEG PDTNTTIIQL QPLQEPESWA RTQSGLQSYL LQFHGLVRLV HQERTLAFPL TIRCFLGCEL PPEGSRAHVF FEVAVNGSSF VSFRPERALW QADTQVTSGV VTFTLQQLNA YNRTRYELRE FLEDTCVQYV QKHISAENTK GSQTSRSYTS LVLGVLVGSF IIAGVAVGIF LCTGGRRC