ENT1_HUMAN » Endogenous retrovirus group S71 member 1 Env polyprotein

ENT1_HUMAN » Endogenous retrovirus group S71 member 1 Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ENT1_HUMAN » Endogenous retrovirus group S71 member 1 Env polyprotein » Envelope polyprotein;HERV-T Env protein;
Hydrophobic Thickness 34.4 ± 3.0 Å
Tilt Angle 34 ± 0°
ΔGtransfer -29.1 kcal/mol
ΔGfold -15.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 575-601 (570-607)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CREB3, Complex: S29A1:CREB3

Domains

AA: 35-605, ENV polyprotein (coat polyprotein)

UniProt annotation for ENT1_HUMAN » Endogenous retrovirus group S71 member 1 Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.

TISSUE SPECIFICITY: Expressed at higher level in thyroid. Expressed at lower level in adrenal, bone marrow, brain, breast, kidney, ovary, placenta, prostate, skin, testis and trachea.

DOMAIN: The CKS-17 immunosuppressive domain is present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo (By similarity).

UniProt features for ENT1_HUMAN » Endogenous retrovirus group S71 member 1 Env polyprotein
SIGNAL 1 38 Potential.
CHAIN 39 626 HERV-T_19q13.11 provirus ancestral Env polyprotein.
REGION 39 438 Surface protein (By similarity).
REGION 439 626 Transmembrane protein (By similarity).
REGION 439 459 Fusion peptide (By similarity).
MOTIF 302 305 CXXC (By similarity).
MOTIF 503 519 CKS-17 (By similarity).
MOTIF 520 528 CX6CC (By similarity).
SITE 438 439 Ancestral cleavage site (Potential).
DISULFID 520 527 By similarity.
Amino Acid Sequence for ENT1_HUMAN » Endogenous retrovirus group S71 member 1 Env polyprotein
MGPEAWVRPL KTAPKPGEAI RLILFIYLSC FFLPVMSSEP SYSFLLTSFT TGRVFANTTW RAGTSKEVSF AVDLCVLFPE PARTHEEQHN LPVIGAGSVD LAAGFGHSGS QTGCGSSKGA EKGLQNVDFY LCPGNHPDAS CRDTYQFFCP DWTCVTLATY SGGSTRSSTL SISRVPHPKL CTRKNCNPLT ITVHDPNAAQ WYYGMSWGLR LYIPGFDVGT MFTIQKKILV SWSSPKPIGP LTDLGDPIFQ KHPDKVDLTV PLPFLVPRPQ LQQQHLQPSL MSILGGVHHL LNLTQPKLAQ DCWLCLKAKP PYYVGLGVEA TLKRGPLSCH TRPRALTIGD VSGNASCLIS TGYNLSASPF QATCNQSLLT SISTSVSYQA PNNTWLACTS GLTRCINGTE PGPLLCVLVH VLPQVYVYSG PEGRQLIAPP ELHPRLHQAV PLLVPLLAGL SIAGSAAIGT AALVQGETGL ISLSQQVDAD FSNLQSAIDI LHSQVESLAE VVLQNCRCLD LLFLSQGGLC AALGESCCFY ANQSGVIKGT VKKVRENLDR HQQERENNIP WYQSMFNWNP WLTTLITGLA GPLLILLLSL IFGPCILNSF LNFIKQRIAS VKLTYLKTQY DTLVNN