ENK7_HUMAN » HERV-K_1q23.3 provirus ancestral Env polyprotein

ENK7_HUMAN » HERV-K_1q23.3 provirus ancestral Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ENK7_HUMAN » HERV-K_1q23.3 provirus ancestral Env polyprotein » Envelope polyprotein;HERV-K(C1a) envelope protein;HERV-K110 envelope protein;HERV-K18 envelope protein;HERV-K18 superantigen;IDDMK1,2 22 envelope protein;IDDMK1,2 22 superantigen;
Hydrophobic Thickness 35.2 ± 2.8 Å
Tilt Angle 2 ± 1°
ΔGtransfer -45.9 kcal/mol
ΔGfold -20.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 518-547 (515-551)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 4-172, Retro-transcribing viruses envelope glycoprotein

AA: 375-572, PDBID: 1AIK, Subunit N, Seq Identity:12%, Retroviral envelope protein

UniProt annotation for ENK7_HUMAN » HERV-K_1q23.3 provirus ancestral Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This envelope protein has superantigenic properties.

FUNCTION: SU mediates receptor recognition.

FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

TISSUE SPECIFICITY: Expressed at higher level in the thymus. Expressed at lower level in peripheral blood lymphocytes.

DEVELOPMENTAL STAGE: High expression in thymocytes. Neither expressed nor inducible in mature T-cells. Inducible in CD2 negative peripheral blood lymphocytes.

INDUCTION: Induced by type I interferons and by Epstein-Barr virus (EBV).

MISCELLANEOUS: Orthologs in Pan troglodytes and Gorilla gorilla.

MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5"-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.

MISCELLANEOUS: Autoantibodies reactive to this envelope are detectable in sera from healthy donors and individuals with autoimmune diseases.

MISCELLANEOUS: Intragenic, in the first intron of CD48 gene.

UniProt features for ENK7_HUMAN » HERV-K_1q23.3 provirus ancestral Env polyprotein
CHAIN 1 560 HERV-K_1q23.3 provirus ancestral Env polyprotein.
CHAIN 1 354 Surface protein (By similarity).
CHAIN 355 560 Transmembrane protein (By similarity).
REGION 355 375 Fusion peptide (Potential).
SITE 354 355 Cleavage (By similarity).
Amino Acid Sequence for ENK7_HUMAN » HERV-K_1q23.3 provirus ancestral Env polyprotein
MVTPVTWMDN PIEVYVNDSV WVPGPTDDRC PAKPEEEGMM INISIGYHYP PICLGRAPGC LMPAVQNWLV EVPTVSPNSR FTYHMVSGMS LRPRVNCLQD FSYQRSLKFR PKGKTCPKEI PKGSKNTEVL VWEECVANSV VILQNNEFGT IIDWAPRGQF YHNCSGQTQS CPSAQVSPAV DSDLTESLDK HKHKKLQSFY LWEWEEKGIS TPRPKIISPV SGPEHPELWR LTVASHHIRI WSGNQTLETR YRKPFYTIDL NSILTVPLQS CVKPPYMLVV GNIVIKPASQ TITCENCRLF TCIDSTFNWQ HRILLVRARE GMWIPVSTDR PWEASPSIHI LTEILKGVLN RSKRFIFTLI AVIMGLIAVT ATAAVAGVAL HSSVQSVNFV NYWQKNSTRL WNSQSSIDQK LASQINDLRQ TVIWMGDRLM TLEHHFQLQC DWNTSDFCIT PQIYNESEHH WDMVRRHLQG REDNLTLDIS KLKEQIFEAS KAHLNLVPGT EAIAGVADGL ANLNPVTWIK TIRSTMIINL ILIVVCLFCL LLVCRCTQQL RRDSDIENGP