ENK6_HUMAN » HERV-K_8p23.1 provirus ancestral Env polyprotein

ENK6_HUMAN » HERV-K_8p23.1 provirus ancestral Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ENK6_HUMAN » HERV-K_8p23.1 provirus ancestral Env polyprotein » EnvK6 protein;Envelope polyprotein;HERV-K115 envelope protein;
Hydrophobic Thickness 31.2 ± 1.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -41.1 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 636-657 (635-662)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 19-105, Rec (regulator of expression encoded by corf) of HERV-K-113

AA: 115-283, Retro-transcribing viruses envelope glycoprotein

AA: 486-683, PDBID: 1AIK, Subunit N, Seq Identity:12%, Retroviral envelope protein

UniProt annotation for ENK6_HUMAN » HERV-K_8p23.1 provirus ancestral Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.

FUNCTION: SU mediates receptor recognition.

FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

MISCELLANEOUS: Insertional polymorphism. Provirus present in 16% of tested individuals.

MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5"-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.

MISCELLANEOUS: Intragenic, in first intron of DEFB107 gene.

UniProt features for ENK6_HUMAN » HERV-K_8p23.1 provirus ancestral Env polyprotein
SIGNAL 1 89 Potential.
CHAIN 90 699 HERV-K_8p23.1 provirus ancestral Env polyprotein.
CHAIN 90 465 Surface protein (By similarity).
CHAIN 466 699 Transmembrane protein (By similarity).
REGION 466 486 Fusion peptide (Potential).
SITE 465 466 Cleavage (By similarity).
Amino Acid Sequence for ENK6_HUMAN » HERV-K_8p23.1 provirus ancestral Env polyprotein
MNPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEEQMKLP STKKAEPPTW AQLKKLTQLA TKYLENTKVT QTPESMLLAA LMIVSMVVSL PMPAGAAVAN YTNWAYVPFP PLIRAVTWMD NPIEVYVNDS VWVPGPIDDR CPAKPEEEGM MINISIGYRY PPICLGRAPG CLMPAVQNWL VEVPTVSPIS RFTYHMVSGM SLRPRVNYLQ DFSYQRSLKF RPKGKPCPKE IPKESKNTEV LVWEECVANS AVILQNNEFG TIIDWAPRGQ FYHNCSGQTQ SCPSAQVSPA VDSDLTESLD KHKHKKLQSF YPWEWGEKRI STPRPKIVSP VSGPEHPELW RLTVASHHIR IWSGNQTLET RDRKPFYTVD LNSSLTLPLQ SCVKPPYMLV VGNIVIKPDS QTITCENCRL LTCIDSTFNW QHRILLVRAR EGVWIPVSMD RPWEASPSVH ILTEVLKGVL NRSKRFIFTL IAVIMGLIAV TATAAVAGVA LHSSVQSVNF VNDGQKNSTR LWNSQSSIDQ KLANQINDLR QTVIWMGDRL MSLEHRFQLQ CDWNTSDFCI TPQIYNDSEH HWDMVRRHLQ GREDNLTLDI SKLKEQIFEA SKAHLNLVPG TEAIAGVADG LANLNPVTWV KTIGSTTIIN LILILVCLFC LLLVCRCTQQ LRRDSDHRER AMMTMAVLSK RKGGNVGKSK RDQIVTVSV