ENK5_HUMAN » HERV-K_19p13.11 provirus ancestral Env polyprotein

ENK5_HUMAN » HERV-K_19p13.11 provirus ancestral Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ENK5_HUMAN » HERV-K_19p13.11 provirus ancestral Env polyprotein » EnvK5 protein;Envelope polyprotein;HERV-K113 envelope protein;
Hydrophobic Thickness 31.2 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -45.8 kcal/mol
ΔGfold -20.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 636-657 (635-662)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 4-172, Retro-transcribing viruses envelope glycoprotein

UniProt annotation for ENK5_HUMAN » HERV-K_19p13.11 provirus ancestral Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.

TISSUE SPECIFICITY: Expressed in lung, placenta, testis, peripheral blood lymphocytes, and teratocarcinoma cell lines.

MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5"-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.

MISCELLANEOUS: Intergenic, closest flanking genes being RPL24 and FLJ23047.

UniProt features for ENK5_HUMAN » HERV-K_19p13.11 provirus ancestral Env polyprotein
SIGNAL 1 89 Potential.
CHAIN 90 699 HERV-K_19p13.11 provirus ancestral Env polyprotein.
CHAIN 90 465 Surface protein (By similarity).
CHAIN 466 699 Transmembrane protein (By similarity).
REGION 466 486 Fusion peptide (Potential).
SITE 465 466 Cleavage (By similarity).
Amino Acid Sequence for ENK5_HUMAN » HERV-K_19p13.11 provirus ancestral Env polyprotein
MNPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEEQMKLP STKKAEPPTW AQLKKLTQLA TKYLENTKVT QTPESMLLAA LMIVSMVVSL PMPAGAAAAN YTYWAYVPFP PLIRAVTWMD NPIEIYVNDS VWVPGPTDDC CPAKPEEEGM MINISIGYRY PPICLGRAPG CLMPAVQNWL VEVPTVSPIS RFTYHMVSGM SLRPRVNYLQ DFSYQRSLKF RPKGKPCPKE IPKESKNTEV LVWEECVANS AVILQNNEFG TLIDWAPRGQ FYHNCSGQTQ SCPSAQVSPA VDSDLTESLD KHKHKKLQSF YPWEWGEKGI STARPKIISP VSGPEHPELW RLTVASHHIR IWSGNQTLET RDRKPFYTID LNSSLTVPLQ SCVKPPYMLV VGNIVIKPDS QTITCENCRL LTCIDSTFNW QHRILLVRAR EGVWIPVSMD RPWEASPSVH ILTEVLKGVL NRSKRFIFTL IAVIMGLIAV TATAAVAGVA LHSSVQSVNF VNDWQNNSTR LWNSQSSIDQ KLANQINDLR QTVIWMGDRL MSLEHRFQLQ CDWNTSDFCI TPQIYNESEH HWDMVRCHLQ GREDNLTLDI SKLKEQIFEA SKAHLNLVPG TEAIAGVADG LANLNTVTWV KTIGSTTIIN LILILVCLFC LLLVYRCTQQ LRRDSDHRER AMMTMVVLSK RKGGNVGKSK RDQIVTVSV