|ENK4_HUMAN » Endogenous retrovirus group K member 9 Env polyprotein » EnvK4 protein;Envelope polyprotein;HERV-K(C6) envelope protein;HERV-K109 envelope protein;|
|Hydrophobic Thickness||31.2 ± 1.6 Å|
|Tilt Angle||1 ± 0°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||635-656 (634-661)|
AA: 114-282, Retro-transcribing viruses envelope glycoprotein
AA: 485-682, Retroviral envelope protein
|UniProt annotation for ENK4_HUMAN » Endogenous retrovirus group K member 9 Env polyprotein|
|FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. FUNCTION: SU mediates receptor recognition. FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity). MISCELLANEOUS: This envelope protein is encoded by a human specific provirus. MISCELLANEOUS: ERVK-9 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5"-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.|
|UniProt features for ENK4_HUMAN » Endogenous retrovirus group K member 9 Env polyprotein|
SIGNAL 1 89 Potential. |
CHAIN 90 698 HERV-K_6q14.1 provirus ancestral Env polyprotein.
CHAIN 90 464 Surface protein (By similarity).
CHAIN 465 698 Transmembrane protein (By similarity).
REGION 465 485 Fusion peptide (Potential).
SITE 464 465 Cleavage (By similarity).
|Amino Acid Sequence for ENK4_HUMAN » Endogenous retrovirus group K member 9 Env polyprotein|
|MNPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEEQMKLP STKKAEPPTW AQLKKLTQLA TKYLENTKVT QTPESMLLAA LMIVSMVVSL PMPAGAAAAN YTNWAYVPFP PLIRAVTWMD NPIEVYVNDS VWVPGPIDDR CPAKPEEEGM MINISIGYRY PICLGRAPGC LMPAVQNWLV EVPIVSPICR FTYHMVSGMS LRPRVNYLQD FSYQRSLKFR PKGKPCPKEI PKESKNTEVL VWEECVANSA VILQNNEFGT IIDWTPQGQF YHNCSGQTQS CPSAQVSPAV DSDLTESLDK HKHKKLQSFY PWEWGEKGIS TPRPKIISPV SGPEHPELWR LTVASHHIRI WSGNQTLETR DRKPFYTVDL NSSLTLPLQS CVKPPYMLVV GNIVIKPDSQ TITCENCRLL TCIDSTFNWQ HRILLVRARE GVWIPVSMDR PWEASPSIHI LTEVLKGVLN RSKRFIFTLI AVIMGLIAVT ATAAVAGVAL HSSVQSVNFV NDGQKNSTRL WNSQSSIDQK LANQINDLRQ TVIWMGDRLM SLEHRFQLQC DWNTSDFCIT PQIYNESEHH WDMVRRHLQG REDNLTLDIS KLKEQIFEAS KAHLNLVPGT EAIAGVADGL ANLNPVTWVK TIGSTTIINL ILILVCLFCL LLVCRCTQQL RRDSDHRERA MMTMAVLSKR KGGNVGKSKR DQIVTVSV|